Words similar to pyrazolopyridine

Example sentences for: pyrazolopyridine

How can you use “pyrazolopyridine” in a sentence? Here are some example sentences to help you improve your vocabulary:

2 is present at much higher concentrations within the cell [ 22 23 ] . This ligand specificity of the NO binding domain of animal SGCs is very similar to bacterial cytochrome c' that likewise binds only NO and CO [ 24 ] . The N-terminal region of the α subunit has been shown to bind certain synthetic pyrazolopyridine ligands, which act as potents NO-independent agonists of cyclase activity [ 25 26 ] .
Interestingly, binding studies on a synthetic pyrazolopyridine SGC agonist, BAY 41-2272 have suggested a role for the region 236-290 of the human SGC1 α-subunit in interacting with this ligand [ 25 26 ] . Though actual cross-linking occurred with cysteine residues situated just N-terminal to the HNOBA domain, it is likely that the rest of domain is involved in contact with the ligand.
Studies on the human SGC1 suggest that the synthetic pyrazolopyridine ligand binds at site distinct from NO and heme, but requires the heme-binding site for its action [ 25 26 ] . This could imply a synergy or cooperation between these domains in heme interation and cyclase activation.