Words similar to pyogenes
Example sentences for: pyogenes
How can you use “pyogenes” in a sentence? Here are some example sentences to help you improve your vocabulary:
In studies using a tissue chamber model, Kotb and colleagues have noted changes in expression of key virulence factors as a function of time [ 40 ] . Thus, it is possible that the in vivo events leading to selection of stable S. pyogenes variants may require a dynamic interaction with the host and that only under certain experimental conditions will the stable variant population be recovered.
The bacteria used in this study were the opacity factor positive M49 Streptococcus pyogenes isolate CS101 and an isogenic β-hemolytic negative variant generated by transposon mutagenesis, CS101 sagA/pel ::Tn 917 [ 4 ] . Todd-Hewitt broth containing 0.3% yeast extract (THY) was obtained from DIFCO (Detroit MI).
Streptococcus pyogenes causes a variety of diseases in man ranging from mild suppurative throat and skin infections like pharyngitis and erysipelas to severe invasive conditions such as necrotizing fasciitis and streptococcal toxic shock syndrome [ 1 ] . One of the most widely recognized putative streptococcal virulence factors is the oxygen-stable hemolysin, streptolysin S (SLS).
For this purpose, we used five closely related genomes in the enterobacteria group: E. coli O157:H7 EDL933 [ 11 ] , E. coli O157:H7 Sakaï [ 29 ] , E. coli K12 [ 30 ] , Salmonella enterica [ 31 ] , and S. typhimurium LT2 [ 10 ] ; three closely related genomes in the alpha-proteobacteria group: Helicobacter pylori J99 [ 32 ] , H. pylori 26695 [ 33 ] , and Campylobacter jejunii [ 34 ] ; and three closely related genomes in the Streptococcus genus: S. pneumoniae R6 [ 35 ] , S. pneumoniae TIGR4 [ 36 ] , and S. pyogenes [ 12 ] . We considered as unambiguous the relationships between these bacteria because, for example, the orthologous genes of the two strains of E. coli O157:H7 are almost identical at the nucleotide level, while they show noticeable differences from E. coli K12 (data not shown).
The biological selection of phenotypic revertants of variants of S. pyogenes from populations with defined mutations in key regulators or promoter regions of putative virulence genes is likely to provide key insights into the pathogenesis of host-bacterial interactions.
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