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Example sentences for: pyogenes
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Selection of β hemolysis positive variants from a sagA/pel mutant of S. pyogenes isolate CS101 were identified.
This is reflected in a skewed topology of the phylogeny, see, for example, the Pseudomonas aeruginosa and Streptococcus pyogenes hypothetical proteins at the bottom of Figure 1. Hence, the PICs correspond to intervals of percent sequence identity, and the greater the number and/or magnitude of outliers in the family, the larger the percent identity interval (see Figure 1).
Previous studies from our laboratory have consistently demonstrated loss of the SpeB phenotype in S. pyogenes isolates injected in a skin air sac and recovered from the organs of lethally infected mice [ 10 16 ] . This selection was not associated with loss of β-hemolysis but was associated with over-expression of M and M-related proteins, which in turn are predictive of the invasive potential of the organism in a skin infection model [ 16 ] . Based on the phenotypic characteristics of the kidney-recovered variant (β-hemolytic positive, M and M-related protein positive and SpeB negative) we predicted that this variant would be as virulent or more virulent than the wild type organism in the mouse skin infection model.
Mfas: Macaca fascicularis , Mjan: Methanococcus jannaschii , Mka: Methanopyrus kandleri , Mlo: Mesorhizobium loti , Mma: Methanosarcina mazei , Mta: Methanothermobacter thermautotrophicus , Mtu: Mycobacterium tuberculosis , Nm: Neisseria meningitidis , Oih: Oceanobacillus iheyensis , Osa: Oryza sativa , Pa: Pyrococcus abyssi , Pae: Pseudomonas aeruginosa , Pfu: Pyrococcus furiosus , Ph: Pyrococcus horikoshii , Pmar: Prochlorococcus marinus , Pmu: Pasteurella multocida , Pyae: Pyrobaculum aerophilum , Rsol: Ralstonia solanacearum , Sa: Staphylococcus aureus , Scoe: Streptomyces coelicolor , Sen: Salmonella enterica , Sme: Sinorhizobium meliloti , Spn: Streptococcus pneumoniae , Spy: Streptococcus pyogenes , Sso: Sulfolobus solfataricus , Ssp: Synechocystis sp.
Streptococcus pyogenes causes a variety of diseases in man ranging from mild suppurative throat and skin infections like pharyngitis and erysipelas to severe invasive conditions such as necrotizing fasciitis and streptococcal toxic shock syndrome [ 1 ] . One of the most widely recognized putative streptococcal virulence factors is the oxygen-stable hemolysin, streptolysin S (SLS).
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