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3) of the human, murine, drosophila, caenorhabditis and yeast proteins disclosed high conservation of the residues previously shown to define the 23-amino acid-long LRRs, including those of yCCR4 and of the adenylyl cyclase (PxxaxxaxxLxxLxLsxNxaxxa, [ 28 ] ), thus suggesting that the function of this motif has been conserved from yeast to mammals.