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Example sentences for: pujana

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The second duplicon recognized within the 600 kb sub-interval was originally described as the Golgin-Linked-to-PML (promyelocytic leukemia) duplicon, or GLP duplicon, by Gilles et al . [ 18 ] and subsequently described as LCR15 by Pujana et al . [ 19 ] , Gratacos et al . [ 20 ] and Pujana et al.
On the basis of the findings of Pujana et al ., the GLP/LCR15 duplicon is present at multiple regions of human genomic instability [ 21 ] . In addition, the GLP/LCR15 duplicon was shown by Gilles et al . to be polymorphic in the human population - showing that these sequences have considerable intraspecific plasticity [ 18 ] . The GLP/LCR15 duplication family has expanded over the last 20 million years of primate evolution, before the divergence of the great ape lineages, resulting in a multitude of copies (estimated at 27) present at multiple sites along chromosome 15, providing the conditions required for rearrangements driven by nonallelic homologous recombination (NAHR) [ 18 19 21 27 ] . We have begun an investigation of the organization of this region within the chimpanzee lineage.