Words similar to pseudo-hexameric

Example sentences for: pseudo-hexameric

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The initial step of the insertion can proceed in the presence of either Mg.ATP or a non-hydrolyzable ATP-analog and involves oligomerization of the BchD and BchI subunits to form an oligomeric ring of AAA protomers that resembles the ring structure of NSF and other AAA proteins [ 14 32 ] . The second step of the insertion involves an obligatory hydrolysis of ATP that is tightly coupled with the transfer of the chelated Mg 2+to the protoporphyrin ring by BchH [ 49 ] . Although the details differ from midasin, particularly with respect to the subunit composition of the AAA ring, this chelation reaction provides a structural model suggesting that the function of the midasin M-domain may be to regulate the ATPase activity of the AAA protomers in the pseudo-hexameric ring and thus couple ATP hydrolysis to the binding of a protein ligand at the MIDAS site.
In most AAA proteins, the ring structure is formed by six identical polypeptide subunits, with each contributing a single AAA protomer [ 14 ] . However, the AAA motor dynein differs in having six distinct AAA protomers disposed in tandem on a single polypeptide subunit of unusually high molecular weight, and it is believed to form a unimolecular pseudo-hexameric AAA ring [ 5 6 16 ] .
Stripped to its fundamentals, the structure of midasin consists of a pseudo-hexameric assembly of AAA protomers associated with a MIDAS-containing M-domain.