Words similar to prototypic
Example sentences for: prototypic
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It is noteworthy that no individual synovial CD4 +memory T cells expressed both IFN-γ and LT-α mRNAs, even though these are the prototypic Th1 cytokines [ 9].
Interestingly, however, ICI 182,780, a prototypic estrogen antagonist, blocked the protective effect of 17β-estradiol on neuronal cell death (P < 0.05) while tamoxifen had only a partial effect that was not significant (Figure 8D).
Initial results showed that CAR is an apparently constitutive transactivator able to activate gene expression in the absence of exogenously added ligands [ 8 9 ] . The first CAR ligands identified, androstanol and androstenol, are inverse agonists that block this constitutive transactivation [ 10 ] . More recently, it has been found that CAR mediates the characteristic response of a subset of drug metabolizing enzymes to a variety of structurally unrelated foreign compounds [ 11 ] . These xenobiotic activators are referred to as "phenobarbital (PB) - like," based on the prototypic effects of the anti-epileptic agent on drug metabolism [ 12 13 14 ] . The most potent activator of murine CAR is the high affinity agonist ligand TCPOBOP (1,4-bis [2-(3,5-dichloropyridyloxy)]benzene) [ 15 16 ] .
In Drosophila , the prototypic homolog of the mammalian Toll-like receptors (Toll) defends against fungal infection [ 18], whereas the protein 18-wheeler defends against bacterial infection [ 19].
It is noteworthy that no individual synovial CD4 +memory T cells expressed both IFN-γ and LT-α mRNA, even though these are the prototypic Th1 cytokines [ 9].
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