Example sentences for: protein-interaction

How can you use “protein-interaction” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Statistical significance was measured by drawing pathways from membrane proteins to DNA-binding proteins through the experimentally determined protein-interaction map (henceforth called "real pathways") and comparing these pathways with pathways drawn through control interaction maps that were created by randomizing all pairwise interactions in the original dataset.

  • Although the protein-interaction dataset we used contained no direct interaction between Ste2p/Ste3p and Ste4p, Ste2p-Ste4p has been shown to interact in a targeted yeast two-hybrid study [ 33 ] .

  • It includes Far1p, a protein necessary for pheromone-induced cell cycle arrest in G1 [ 11 ] , Mpt5p, a protein necessary for recovery from cell cycle arrest [ 12 ] , and Bem1p and Sph1, both of which are necessary for establishment of cell polarity during shmooing and budding [ 13 14 ] . In our protein-interaction map there is no direct interaction between a pheromone receptor (Ste2p or Ste3p) and any component of the heterotrimeric G protein complex (Ste4p/Ste18p/Gpa1p), so NetSearch drew indirect paths through Akr1p, a known inhibitor of signaling in the pheromone pathway [ 15 ] . The predicted network does not include the GTPase Cdc42p (paths were instead drawn preferentially through its cofactor Cdc24p, which physically interacts with Ste4p) or Ste20p, because of missing interactions in the protein-interaction map.

  • 4Bdepicts the pheromone response network at several different score cutoffs, and demonstrates how higher co-clustering score cutoffs reduces the complexity of the protein-interaction map.

  • Until we have a more complete protein-interaction set, a user who wishes to explore a particular pathway http://arep.med.harvard.edu/NetSearchneeds to specify pathway starting points and ending points (such as membrane and DNA-binding proteins, respectively).


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