Example sentences for: protein-coupled

How can you use “protein-coupled” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • An additional feature of OR carboxyl termini is a high content of positively charged amino-acid residues occurring in a positionally conserved pattern, a not uncommon feature of many other G-protein-coupled receptors.

  • Furthermore, since some GPCRs can modulate MAP kinase activity, MAP kinase regulation of GPCR function may then serve as a form of negative feedback control in much the same way that protein kinase A, protein kinase C and the G protein-coupled receptor kinases (GRKs) regulate GPCRs.

  • Recent in vitro observations that α-synuclein is phosphorylated by G protein-coupled receptor kinases, and that this phosphorylation relieves its inhibitory action on PLD2 [ 40 ] , suggest a novel mechanism by which neurotransmitter receptors (including muscarinic receptors) might modulate PLD2 activity.

  • For example, DISC1 modulates neurite outgrowth, there is an extensive literature on the involvement of NRG1 in the development of the CNS, and RGS4 may modulate intracellular signaling for many G-protein-coupled receptors.

  • Taking the G protein-coupled receptors (GPCRs) as an example, after agonist action, GPCRs activate G proteins and become phosphorylated by G protein-coupled receptor kinases [ 23 ] . This event promotes activation of effector enzymes and ion channels by the activated Gα GTP.


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