Words similar to protegrin
Example sentences for: protegrin
How can you use “protegrin” in a sentence? Here are some example sentences to help you improve your vocabulary:
The acyl chains of lipid A form an integral part of the outer membrane bilayer, and electrostatic or hydrophobic binding of protegrin to lipid A could easily disturb the organization and acyl-chain packing of the outer membrane, both vital in maintaining its integrity and barrier function.
5 μg 125I-GGPG /ml, approximately sixfold more protegrin molecules bound to P. aeruginosa than to B. cepacia , and at an 125I-GGPG concentration of 25 μg/ml, 12 times as many protegrin molecules bound to P. aeruginosa . Another factor also merits mention in this regard.
Resistance to polymyxin B is also imparted by the absence or masking of critical binding sites required for polycation-mediated permeabilization of the outer membrane [ 54 ] . Thus, attachment of polymyxin B to Yersinia enterocolitica is reduced by steric hindrance generated by the size and/or branched shape of the outer core region of its LPS macromolecule [ 55 ] . Additionally, resistance to cationic peptides can be due to cytoplasmic clearance of the antimicrobial peptide by an efflux pump; e.g., Yersinia resistance to polymyxin B caused by the RosA/RosB efflux pump/potassium antiporter [ 56 ] and Neisseria gonorrhoeae resistance to protegrin PG-1 via an energy-dependent efflux system termed mtr [ 57 ] .
P. aeruginosa lipid A phosphates are unmodified, and if these phosphates are principal protegrin binding sites, then one would expect exactly the results shown in Fig.
Incubation of 125I-GGPG with intact P. aeruginosa 9027 (PG-1 sensitive) and B. cepacia 25416 (PG-1 resistant) cells demonstrated a marked difference in protegrin binding between the two strains (Fig.
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