Words similar to protegrin
Example sentences for: protegrin
How can you use “protegrin” in a sentence? Here are some example sentences to help you improve your vocabulary:
P. aeruginosa lipid A phosphates are unmodified, and if these phosphates are principal protegrin binding sites, then one would expect exactly the results shown in Fig.
5 μg 125I-GGPG /ml, approximately sixfold more protegrin molecules bound to P. aeruginosa than to B. cepacia , and at an 125I-GGPG concentration of 25 μg/ml, 12 times as many protegrin molecules bound to P. aeruginosa . Another factor also merits mention in this regard.
In model systems, the ability of protegrins to permeabilize membranes shows pronounced "concentration-gating", an indication that it is influenced by the density of bound protegrin molecules per unit area of membrane [ 47 ] . As prior quantitative studies of peptide binding are few in number, some readers may be surprised to note that Fig.
5show that B. cepacia and P. aeruginosa LPS bound equivalent amounts of PG-1 at high (10-20 μM) protegrin concentrations.
Resistance to polymyxin B is also imparted by the absence or masking of critical binding sites required for polycation-mediated permeabilization of the outer membrane [ 54 ] . Thus, attachment of polymyxin B to Yersinia enterocolitica is reduced by steric hindrance generated by the size and/or branched shape of the outer core region of its LPS macromolecule [ 55 ] . Additionally, resistance to cationic peptides can be due to cytoplasmic clearance of the antimicrobial peptide by an efflux pump; e.g., Yersinia resistance to polymyxin B caused by the RosA/RosB efflux pump/potassium antiporter [ 56 ] and Neisseria gonorrhoeae resistance to protegrin PG-1 via an energy-dependent efflux system termed mtr [ 57 ] .
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