Words similar to propylthiouracil
Example sentences for: propylthiouracil
How can you use “propylthiouracil” in a sentence? Here are some example sentences to help you improve your vocabulary:
The drugs have been studied with relation to their effect in Graves' hyperthyroidism which, like psoriasis, is an autoimmune disorder [ 9 10 11 12 ] Antithyroid thioureylenes, of which propylthiouracil, methimazole and carbimazole are used in clinical practice, have known immunomodulatory properties [ 13 14 ] and, in the case of psoriasis, also have antiproliferative effects as demonstrated by their ability to produce a decline in markers of cellular proliferation such as proliferative cell nuclear antigen (PCNA) [ 15 ] .
The present study was performed to examine the effect of propylthiouracil treatment of patients with plaque psoriasis on CD1a expression in their psoriatic lesions in order to determine whether this form of therapy resulted in depletion of APCs from affected skin, that could account for the therapeutic benefit of PTU in this disorder.
IL-12, a product of Langerhans cells and skin monocytes plays a pivotal role in T-cell activation that leads to formation of the psoriatic plaque [ 22 ] . IL-12 levels are also significantly raised in patients with Graves' hyperthyroidism and are reduced following treatment with propylthiouracil [ 23 ] .
The number of CD-1a staining cells showed an apparent increase after propylthiouracil therapy.
[ 1 2 ] Treatment of the disease results in costs that range between 0.7 to more than 4 billion dollars annually in the US alone [ 3 ] . One of the most cost-effective forms of potential treatment for the disease is the use of antithyroid thioureylenes such a propylthiouracil.
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