Example sentences for: proposition

How can you use “proposition” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The essence of the story, which I found on the hidden gem of the Internet, mediagossip.com, is that he hasn't broken any stories since Monica and has seen his unique selling proposition usurped by other would-be Web Winchells.

  • While a social conservative, Bush is immigrant-friendly (he opposed Proposition 187) and keeps quiet about his pro-life position.

  • The Supreme Court's decision Monday to let California's anti-affirmative action Proposition 209 stand leads at USA Today , the Washington Post and the Los Angeles Times . The New York Times leads with the emerging Republican congressional campaign against Clinton administration small-scale health care reform--and sticks the 209 victory deep inside, on p.

  • The vote on Proposition 227 is evidence of the public will, says Gigot--the people reject screwy ideas such as bilingual education.

  • Modulation of this mitogenic pathway occurs in part via the M6P/IGF2R, which functions in the internalization and degradation of IGF-II [ 10 ] . M6P/IGF2R is also important in activation of TGF-β, a potent growth inhibitor for most cell types, and in binding, transport and activation of lysosomal enzymes, such as cathepsins [ 12 13 ] . It has been shown that M6P/IGF2R expression is significantly reduced in both rat and human hepatocellular carcinomas [ 14 ] . Loss of hetorozygosity (LOH) at the M6P/IGF2 receptor gene locus on 6q26-27 coupled with somatic point mutations in the remaining allele has recently been demonstrated in liver and breast cancers [ 15 16 17 18 19 20 21 22 23 ] . In addition, somatic mutations of the M6P/IGF2R gene were also found in prostate cancer, lung carcinoma, and genetically unstable cancers of the endometrium, brain, stomach and colorectum [ 24 25 26 27 28 29 ] . The findings of LOH and mutations of M6P/IGF2R in a wide variety of tumor types have led to the proposition that the M6P/IGF2R is a tumor suppressor gene.


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