Words similar to promyelocytic
Example sentences for: promyelocytic
How can you use “promyelocytic” in a sentence? Here are some example sentences to help you improve your vocabulary:
To examine whether differentiation and reorganization of the cytoskeleton produces changes in mRNA distribution, macrophage differentiation was induced by the addition of 10 nM TPA to suspension cultures of exponentially proliferating HL-60 promyelocytic cells.
Suspended HL-60 promyelocytic leukemia cells were cultured in IMDM (Clonetics) supplemented with 10% fetal bovine serum (Hyclone).
HL-60 promyelocytic leukemia cells have been widely used as a model system for the study of hematopoietic differentiation because they undergo terminal differentiation to one of several cell types of the myelo-monocytic lineage when stimulated with various pharmacological agents [ 21 ] . In particular, induction of macrophage differentiation by treatment of HL60 cells with TPA is accompanied by dramatic alterations in cell morphology and cytoskeleton structure.
The HL-60 human promyelocytic leukemia cell line responds in culture to sub-micromolar concentrations of retinoic acid ( all-trans and 13-cis ) by undergoing terminal differentiation to a granulocytic cell with the ability to phagocytose and reduce nitroblue tetrazolium [ 28 ] . The response to retinoic acid in HL-60 cells is dependent on the expression of the retinoic acid receptor RAR α [ 29 ] . The use of all-trans retinoic acid in differentiation therapy for patients with acute promyelocytic leukemia has resulted in prolonged, complete remissions when combined with cytotoxic chemotherapy, and may provide complete, long-term remissions as a single agent [ 30 ] .
To explore this possibility, we used gene microarray technology to identify and analyze large populations of cytosolic and cytoskeleton-associated mRNAs isolated from HL-60 promyelocytic cells.
Loading...