Words similar to promyelocytic
Example sentences for: promyelocytic
How can you use “promyelocytic” in a sentence? Here are some example sentences to help you improve your vocabulary:
The second duplicon recognized within the 600 kb sub-interval was originally described as the Golgin-Linked-to-PML (promyelocytic leukemia) duplicon, or GLP duplicon, by Gilles et al . [ 18 ] and subsequently described as LCR15 by Pujana et al . [ 19 ] , Gratacos et al . [ 20 ] and Pujana et al.
HL-60 promyelocytic leukemia cells have been widely used as a model system for the study of hematopoietic differentiation because they undergo terminal differentiation to one of several cell types of the myelo-monocytic lineage when stimulated with various pharmacological agents [ 21 ] . In particular, induction of macrophage differentiation by treatment of HL60 cells with TPA is accompanied by dramatic alterations in cell morphology and cytoskeleton structure.
Suspended HL-60 promyelocytic leukemia cells were cultured in IMDM (Clonetics) supplemented with 10% fetal bovine serum (Hyclone).
The HL-60 human promyelocytic leukemia cell line responds in culture to sub-micromolar concentrations of retinoic acid ( all-trans and 13-cis ) by undergoing terminal differentiation to a granulocytic cell with the ability to phagocytose and reduce nitroblue tetrazolium [ 28 ] . The response to retinoic acid in HL-60 cells is dependent on the expression of the retinoic acid receptor RAR α [ 29 ] . The use of all-trans retinoic acid in differentiation therapy for patients with acute promyelocytic leukemia has resulted in prolonged, complete remissions when combined with cytotoxic chemotherapy, and may provide complete, long-term remissions as a single agent [ 30 ] .
To explore this possibility, we used gene microarray technology to identify and analyze large populations of cytosolic and cytoskeleton-associated mRNAs isolated from HL-60 promyelocytic cells.
Loading...