Words similar to promyelocytic
Example sentences for: promyelocytic
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HL-60 promyelocytic leukemia cells have been widely used as a model system for the study of hematopoietic differentiation because they undergo terminal differentiation to one of several cell types of the myelo-monocytic lineage when stimulated with various pharmacological agents [ 21 ] . In particular, induction of macrophage differentiation by treatment of HL60 cells with TPA is accompanied by dramatic alterations in cell morphology and cytoskeleton structure.
Suspended HL-60 promyelocytic leukemia cells were cultured in IMDM (Clonetics) supplemented with 10% fetal bovine serum (Hyclone).
have previously monitored gene expression at various time points following phorbol ester-induced differentiation in the same HL-60 cell system [ 22 ] . Thirteen of the 22 transcripts we identified as cytoskeleton-associated were also assayed in that study by Tamayo, et al [ 22 ] . Only two of these transcripts-alpha spectrin and pim-1 were found to vary significantly, in that the expression of both genes was undetectable in the promyelocytic cell type and increased dramatically upon differentiation to the macrophage cell type.
To examine whether differentiation and reorganization of the cytoskeleton produces changes in mRNA distribution, macrophage differentiation was induced by the addition of 10 nM TPA to suspension cultures of exponentially proliferating HL-60 promyelocytic cells.
To investigate whether multiple mRNAs associate with the cytoskeleton, exponentially growing HL-60 promyelocytic cells were biochemically extracted to obtain fractions enriched for either cytoskeleton or cytosolic components.
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