Example sentences for: proinflammatory

How can you use “proinflammatory” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In addition to the effects of IL-4 on antibody production, this cytokine inhibits Th1 responses, including IFN-γ and macrophage production of proinflammatory cytokines [ 25, 26].

  • A deficiency of TTP is associated with a profound proinflammatory phenotype.

  • The proinflammatory cytokines tumor necrosis factor alpha, IL-1, and IL-6 augment osteoclastogenesis [ 9 10 11 ] , while IL-10, IL-12, IL-18, and IFN-γ antagonize osteoclastogenesis in vitro [ 12 13 14 15 ] . It is probable that cytokines play a vital role in the delicate balance of bone remodeling, and that therapies based upon their natural biological function can be designed.

  • IL-10 is a potent monocyte/macrophage regulatory cytokine that inhibits expression of proinflammatory mediators [ 1 2 ] . Monocytes/macrophages, B cells, murine Th2 cells, and some CD8 +cells produce IL-10 [ 3 4 ] . Macrophages rapidly produce proinflammatory cytokines such as tumor necrosis factor alpha (TNF-α), IL-1 and IL-12 after activation with lipopolysaccharide or IFN-γ, while production of IL-10 is delayed.

  • Increased serum leptin levels in obesity and metabolic syndrome support the view that these disorders are in fact low-grade systemic inflammatory diseases, characterized by increased concentrations of proinflammatory cytokines like interleukin-6, tumor necrosis factor-α and leptin.


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