Words similar to proinflammatory
Example sentences for: proinflammatory
How can you use “proinflammatory” in a sentence? Here are some example sentences to help you improve your vocabulary:
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that may play a role in several disease states, including arthritis, sepsis, Crohn's disease, allograft rejection, asthma and prostate cancer [ 1 2 3 ] . Although MIF was initially described as released from activated T-cells [ 4 5 ] , subsequent investigations have localized MIF in a variety of other cells and tissues (for a recent review [ 1 ] ). For example, pre-formed MIF stores can be found in the epithelia of several organs and may be released in response to endotoxemia [ 6 ] . The role of MIF in the central nervous system remains to be determined, yet neurons in the brain synthesize and rapidly release MIF while glial cells appear to store MIF [ 7 8 ] , and the anterior pituitary gland contains MIF that may be released during endotoxemia [ 9 ] .
Treatment with rhIL-11 decreases the production of proinflammatory cytokines, including tumor necrosis factor (TNF)-α and interleukin (IL)-1β, and inhibits NF-κB binding activity [ 2, 3, 4].
Lee et al [ 71 ] found that in both brain regions, one hallmark of aging was enhanced gene expression of the inflammatory response, including proinflammatory peptides and many interferon-related proteins.
Thus, it is possible that, in RA, there is biased differentiation of IFN-γ-secreting proinflammatory Th1 CD4 +T cells, and insufficient differentiation of immunoregulatory IL-4-producing Th2 cells.
IL-4 can down-regulate the production of proinflammatory and Th1-type cytokines by inducing mRNA degradation and upregulating the expression of inhibitors of proinflammatory cytokines such as IL-1Ra [ 3, 4].
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