Example sentences for: proinflammatory

How can you use “proinflammatory” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • TNF is a predominant proinflammatory cytokine, particularly in sepsis and chronic inflammatory disorders suggesting that the role of its negative regulator, TTP, may be of functional importance in the development and pathogenesis of disease.

  • A deficiency of TTP is associated with a profound proinflammatory phenotype.

  • Also, mRNA expression of proinflammatory cytokines TNF-α, Interferon-γ and cyclins G1, and E were significantly decreased and the expression of TGF-β and p21 were increased.

  • Cigarette smoke has been shown by others to induce a synthesis of glutathione and gamma-glutamylcysteine that was associated with transcription factor AP-1 or an AP-1-like response element [ 9 ] . Although MAPKs and NFκB have been implicated in the upregulation of proinflammatory cytokines, the role of these pathways in normal human pulmonary epithelial cells in response to CSC has not been investigated.

  • Once IL-10 is produced it functions in an autoregulatory fashion to suppress proinflammatory cytokine mRNA expression and protein production [ 5 6 7 ] . In addition, IL-10 suppresses the expression of MHC class II molecules and costimulatory molecules such as intercellular adhesion molecule 1 and B7, leading to reduction in T-cell macrophage interactions [ 8 9 10 ] .


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