Words similar to profilin
Example sentences for: profilin
How can you use “profilin” in a sentence? Here are some example sentences to help you improve your vocabulary:
It should be noted that besides profilin, there are many other cellular proteins known to modulate actin filamentation and cytoskeletal dynamics, and profilin itself binds to a large number proteins, many with poly-proline sequences [ 42 43 ] . Clearly, identification of the various members of the cytoskeletal signaling pathway will constitute an important step in understanding host-RSV interaction, and may lead to additional targets for pathological intervention.
As stated earlier, the syncytium has been considered important for virus spread and pathology [ 17 ] . Because profilin was obviously important in bringing about cytoskeletal changes, it was logical to ask whether profilin also contributes to the fusion of cell membranes.
The ability of soluble monomeric G-actin to polymerize into filamentous F-actin in a reversible manner is central to the cellular function of actin [ 1 2 ] . Rearrangement of actin is promoted rapidly by extracellular stimuli, and is facilitated by sets of actin-associated proteins, one of which is profilin [ 2 ] . It is now appreciated that a large number of cellular parasites co-opt actin for their gene expression and replication in the host cell [ 3 4 ] . Due to its primary role in pediatric respiratory disease, and the enormous human and economic toll it exacts throughout the world, the respiratory syncytial virus (RSV) and its interaction with the host cell have received serious attention.
To sum up, profilin can act as a major liaison between viral proteins and actin, and articulate multiple outcomes for both the cell and the virus, involving signal transduction as well as cytoskeletal changes (Fig.
To answer this question, we knocked down profilin by siRNA as before, infected the cells with RSV, and looked for syncytia at various time points.
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