Words similar to profilin
Example sentences for: profilin
How can you use “profilin” in a sentence? Here are some example sentences to help you improve your vocabulary:
The cellular proteins in this pathway are also evolutionarily conserved, and indeed, HEp-2 and A549 cells express comparable amounts of RhoA, profilin, and actin (data not shown).
If this function of profilin is mediated through actin, results from A549 cells suggest that the actin filaments (F-actin) involved in syncytium must be smaller that stress fibers, and not discernible by light microscopy.
The functionality of the RhoA of A549 cells is substantiated by a number of previous studies, such as the need for RhoA in bradykinin-mediated activation of NF-kappa B [ 35 ] , and the abrogation of H 2 O 2 -mediated activation of JNK by RhoA antisense oligonucleotide [ 36 ] . Profilin purified from A549 cells is also indistinguishable from HEp-2 cell profilin, in terms its molecular weight, pI, affinity for poly-proline, and ability to stimulate actin-dependent transcription of RSV genome in vitro [ 11 ] . Thus, the inability of A549 cells to elicit actin stress fibers is likely due to an as yet unidentified factor or pathway that may be altered or missing in the A549 cells.
Profilin binds to viral transcriptional proteins, N and P, but makes only a small contribution in viral transcription; perhaps these interactions allow docking of the viral RNP complex to the actin filaments.
Because profilin stimulated RSV transcription in vitro [ 11 ] and associated with viral transcriptional proteins, N and P, the obvious next question was to ask how important profilin was for viral gene expression in the intact RSV-infected cell.
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