Words similar to pro-inflammatory
Example sentences for: pro-inflammatory
How can you use “pro-inflammatory” in a sentence? Here are some example sentences to help you improve your vocabulary:
Furthermore, CDDO decreased the expression of the pro-inflammatory mediator Bcl-3, suggesting one possible mechanism of action.
MIF is a pro-inflammatory cytokine that may play a crucial role in initiating or maintaining several inflammatory conditions [ 1 ] . In experimental models, treatment with antibodies to MIF, reversed or prevented colitis and gastric ulcer formation [ 23 24 ] . MIF is upregulated in neurons in the brain and released into the CSF following intracisternal LPS or spinal cord injury [ 7 21 ] . In addition, MIF is upregulated in the brain after reperfusion subsequent to ischemia [ 25 ] . Therefore, MIF is likely involved in the brain's response infectious agents or trauma.
Two highly conserved responses are observed under conditions of endoplasmic reticulum (ER) stress; the ER overload and unfolded protein responses [ 24 25 ] . The unfolded protein response is characterized by generalized suppression of protein synthesis and the specific induction of ER-resident proteins and GADD153 [ 24 ] . The transcription factor nuclear factor kB is activated during the ER overload response, leading to the downstream induction of pro-inflammatory proteins [ 25 ] . Therefore, the transcriptional modulation of GADD153 and IkB by mefloquine suggests that the ER might be a target of the drug.
A strong candidate is TNF itself, as it encodes the potent pro-inflammatory cytokine TNF, and there is a significant body of clinical and experimental data suggesting a causal role for it in the pathogenesis of many of the diseases with which it has been associated.
MAdCAM-1 is a 60 kDa endothelial cell surface molecule that is strongly expressed by mucosal endothelial cells, particularly following exposure of these cells to pro-inflammatory cytokines such as TNF-α.
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