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Example sentences for: presenting
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Presenting Conclusions and Recommendations
Recent reports suggest an active role played by the T cell cytoskeleton in maintaining spatially defined molecular clusters found within the immunological synapse - a highly structured molecular array defined by contact regions between T cells and antigen presenting cells [ 4 5 6 7 ] , and reviewed in [ 8 9 ] or NK cells and target cells [ 10 ] . Although the actin cytoskeleton has been implicated in all these processes, perhaps its greatest role is in regulating T lymphocyte motility and morphology.
To be included in the study, young adults had to meet the following criteria: 1) be of Caucasian ethnicity; 2) be between the ages of 32-38 y; 3) be free from diagnosed endocrine conditions that could have led to obesity, 4) not having taken any medication affecting body weight, 5) presenting a BMI ≥ 25 at adult age; 6) presenting abnormal glucose and/or lipid profiles; 7) presenting at least 2 risk factors for cardiovascular diseases as explained earlier, and having been seen by their physicians between 1974 to 2000.
T-lymphocytes expressing the α:β T-cell antigen receptor (TCR) consist of two major subsets: T cells expressing the CD4 surface glycoprotein, which are restricted by the major hystocompatibility complex (MHC) class II proteins, and CD8 +T cells, which interact with antigen presented by MHC class I proteins [ 1 ] . CD4 and CD8 molecules bind to monomorphic regions on class II and class I MHC proteins respectively, thereby increasing the avidity in the interaction of the TCR with antigen presenting cells [ 2 ] . An intriguing question concerns to the mechanism by which selection and tolerance to self-components is mediated in developing lymphocytes.
In 24 children with inherited disorders of fatty acid oxidation, conduction defects or arrhythmias were the predominant presenting feature [ 14 ] . Arrhythmias in association with hepatomuscular symptoms and hyperammonemia have also been demonstrated in cases of carnitine-acylcarnitine translocase deficiency whose presenting features also include neonatal distress, convulsions, hypoglycemia, hypoketonemia, intermittent dicarboxylic aciduria, hypothermia, apnea, neurological deterioration, and hypocarnitinemia with grossly elevated acylcarnitines [ 15 ] . The accumulation of arrhythmogenic metabolites of fatty acids, such as long chain acylcarnitines, may be responsible for the observed lethal cardiac defects.