Words similar to premenopause

Example sentences for: premenopause

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From the ovarian sex steroids, the role of diminishing estrogen levels is questionable, since the levator ani muscle fibers do not express estrogen receptor alpha [ 2 26 ] . It is not known if estrogen receptor beta is expressed, but levator ani muscle fibers show nuclear expression of progesterone and androgen receptors [ 26 ] . Altered ovarian function in the premenopause can be observed as early as age 43 years, and includes hyperestrogenism and hypergonadotropism, accompanied by decreased progesterone secretion [ 27 ] . During the transition from pre- to postmenopause both estrogen and androgen levels also decline [ 28 ] . These hormonal alterations may well be responsible for the increased gynecological morbidity that characterizes this period of life, including structural and molecular changes in levator ani muscle and increasing incidence of pelvic floor disorders.