Words similar to pregenomic

Example sentences for: pregenomic

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The replication of hepadnaviral DNA is initiated by the interaction of the viral reverse transcriptase (P) with an RNA stem-loop (∈) within a terminal duplication of the pregenomic RNA.
This nascent DNA then acts as a primer for the synthesis of full length minus-strand DNA templated by the pregenomic RNA [ 5, 6, 7, 8, 9, 10].
The hepadnaviral P protein possesses many unique features relative to the better studied reverse transcriptases of the retroviruses: (i) it uses its own amino-terminal domain as a protein primer for initiation of DNA synthesis [ 7, 9, 10], (ii) it cannot be isolated in an active form from virions without partial proteolysis or denaturation [ 13, 14, 15], and (iii) under normal circumstances it is active only on the endogenous pregenomic RNA that is encapsidated with it in the viral cores [ 16].
During synthesis of the minus-strand DNA the pregenomic RNA is degraded by the ribonuclease H (RNAseH) activity of P. However, the RNAseH activity does not digest the extreme 5' end of the template RNA, and this ∼ 18 nucleotide capped RNA fragment is then transferred to direct repeat 2 (DR2), where it acts as a primer for synthesis of plus-strand DNA [ 11, 12].
Hepadnaviruses are small, enveloped hepatotropic viruses which replicate by reverse transcription of a pregenomic RNA molecule [ 1; for reviews see 2, 3, 4].