Words similar to pre-pubertal
Example sentences for: pre-pubertal
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In conclusion, our data suggest that the presence of high concentrations of ABP in the mouse seminiferous tubules results in a dramatically increased wave of germ cell apoptosis during the pre-pubertal period.
[ 26 ] ). This would also indicate that the pre-pubertal wave of apoptosis is regulated, at least in part, by T. Indeed, it has been reported that experimental reduction in the levels of intra-testicular T leads to the activation of caspase-3 [ 56 ] and thereby to an increase in germ cell apoptosis [ 57 58 ] . The roles of other apoptosis-regulating proteins, such as the Fas/Fas ligand system [ 47 59 60 ] , the Bcl-2 family of proteins [ 61 62 ] , and several "inhibitor of apoptosis" proteins (IAP) are also likely to play a role in germ cell death and survival [ 63 64 65 ] .
The most convincing evidence comes from a study of peak BMD in a group of pre-pubertal girls [ 10], which confirms the relationship between VDR gene polymorphism and BMD.
Taken together, the presence of increased levels of intra-testicular ABP in the TG mice after 7 days of age [ 25 26 ] and a wave of germ cell apoptosis seen in normal mice at 21 and 30 days of age in this study and by Rodriguez et al . [ 3 ] suggest that the heightened apoptotic wave found in our TG mice during the pre-pubertal period may be regulated by ABP.
Apoptotic cells were identified by the TdT-mediated dUTP-biotin nick end labeling (TUNEL) method and detected either by flow cytometry [ 27 ] or by light microscopy in histological sections [ 28 ] . The results indicate that transgenic ABP alters the rate of testicular germ cell apoptosis throughout life, but it is most likely to cause its germ-cell depleting effect by promoting germ cell apoptosis during the critical pre-pubertal period ("puberty" in laboratory rodents occurs at 50-60 days of life and is defined as the first appearance of spermatozoa in the tail of the epididymis [ 29 30 ] ).
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