Words similar to pre-osteoclasts

Example sentences for: pre-osteoclasts

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Interestingly, IFN-γ-induced STAT1 phosphorylation and nuclear translocation was retained in pre-osteoclasts (Fig.
The retention of Jak-STAT1 signaling in RANKL-stimulated pre-osteoclasts is intriguing, given their demonstrated insensitivity to IFN-γ.
These IFN-γ-resistant pre-osteoclasts produced low levels of NO upon IFN-γ stimulation and were resistant to IFN-γ-induced, Mac-1-induced and RANKL-induced surface expression, suggesting a broad resistance to the cellular effects of IFN-γ.
We demonstrate that pre-osteoclasts stimulated with RANKL for 2 days are rendered resistant to the IFN-γ induced inhibition of osteoclastogenesis, NO production, and upregulation of CD11b and RANK surface expression.
In contrast, Wei et al . have demonstrated that pre-osteoclasts do not lose their potential to differentiate into mature osteoclasts following a similar exposure to IL-4 [ 50 ] . It thus appears that IFN-γ anti-osteoclast activity is mediated by inducing terminal differentiation away from the osteoclast lineage, while IL-4 directly interferes with RANKL signaling during osteoclastogenesis.