Example sentences for: pre-osteoclasts

How can you use “pre-osteoclasts” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Interestingly, IFN-γ-induced STAT1 phosphorylation and nuclear translocation was retained in pre-osteoclasts (Fig.

  • These IFN-γ-resistant pre-osteoclasts produced low levels of NO upon IFN-γ stimulation and were resistant to IFN-γ-induced, Mac-1-induced and RANKL-induced surface expression, suggesting a broad resistance to the cellular effects of IFN-γ.

  • We demonstrate that pre-osteoclasts stimulated with RANKL for 2 days are rendered resistant to the IFN-γ induced inhibition of osteoclastogenesis, NO production, and upregulation of CD11b and RANK surface expression.

  • The retention of Jak-STAT1 signaling in RANKL-stimulated pre-osteoclasts is intriguing, given their demonstrated insensitivity to IFN-γ.

  • These results show that late pre-osteoclasts are capable of signaling via JAK-STAT1, and suggest that signaling events distal to TRAF6 and STAT1 modulate the resistance of these cells to IFN-γ.


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