Words similar to pre-osteoclasts

Example sentences for: pre-osteoclasts

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The retention of Jak-STAT1 signaling in RANKL-stimulated pre-osteoclasts is intriguing, given their demonstrated insensitivity to IFN-γ.
Interestingly, IFN-γ-induced STAT1 phosphorylation and nuclear translocation was retained in pre-osteoclasts (Fig.
These IFN-γ-resistant pre-osteoclasts produced low levels of NO upon IFN-γ stimulation and were resistant to IFN-γ-induced, Mac-1-induced and RANKL-induced surface expression, suggesting a broad resistance to the cellular effects of IFN-γ.
These data support the hypothesis that sensitivity to IFN-γ decreases with increasing osteoclast differentiation and that the mechanism by which RANKL and IFN-γ reciprocally inhibit each other in pre-osteoclasts is mediating the irreversible commitment into the osteoclast or activated macrophage lineages.
These results show that late pre-osteoclasts are capable of signaling via JAK-STAT1, and suggest that signaling events distal to TRAF6 and STAT1 modulate the resistance of these cells to IFN-γ.