Words similar to pre-m
Example sentences for: pre-m
How can you use “pre-m” in a sentence? Here are some example sentences to help you improve your vocabulary:
Our data suggests that nmt55/p54 nrbmay be critical to cell growth and function, such that, decreased nmt55/p54 nrbexpression in ER- human breast tumors or the expression of nmt55/p54 nrbvariants in ER+ tumors may indicate loss of normal growth, nmt55/p54 nrbhas been shown in several studies to bind RNA and interact with PSF and Topoisomerase I [ 14 16 17 18 19 20 39 ] . Those results along with our observations that nmt55/p54 nrbassociates with several splicing factors essential for spliceosome formation (unpublished) and relates to tumor hormonal status [ 13 ] suggest that nmt55/p54 nrbmay be involved in pre-mRNA processing.
Nova-1 regulates the alternative splicing of the pre-mRNAs encoding neuronal inhibitory glycine receptor α2 (GlyR α2) [ 23 ] . The ability of Nova-1 to activate exon selection in neurons is antagonized by a second RNA-binding protein, brPTB (brain-enriched polypyrimidine tract-binding protein), which interacts with Nova-1 and inhibits its function [ 24 ] . DAZAP1 could function in a similar manner by binding to DAZL and inhibiting its function.
Alternative splicing can produce two (or more) distinct non-overlapping protein products from a single pre-mRNA species; we identified 12 such cases (for example, Vanaso and α- Spec , see Figure 7).
However, this possibility contradicts current models of exon definition in which exons in pre-mRNA are first defined by proteins interacting across exons and then processed as relatively autonomous units.
Although an RNA splicing protein, hnRNP A2/B1, has been used as a tumor marker in lung cancer progression [ 47 ] , this is the first time that a protein involved in pre-mRNA splicing has been implicated in breast cancer progression and may represent an important breast tumor marker.
Loading...