Words similar to pre-m
Example sentences for: pre-m
How can you use “pre-m” in a sentence? Here are some example sentences to help you improve your vocabulary:
The methylation of arginine residues has been shown to take place in other pre-mRNA splicing proteins though the role of this modification is unknown [ 38 ] . One approach to determine the presence of a point mutation or a splice variant is to perform PCR coupled with sequencing techniques.
Although an RNA splicing protein, hnRNP A2/B1, has been used as a tumor marker in lung cancer progression [ 47 ] , this is the first time that a protein involved in pre-mRNA splicing has been implicated in breast cancer progression and may represent an important breast tumor marker.
Nova-1 regulates the alternative splicing of the pre-mRNAs encoding neuronal inhibitory glycine receptor α2 (GlyR α2) [ 23 ] . The ability of Nova-1 to activate exon selection in neurons is antagonized by a second RNA-binding protein, brPTB (brain-enriched polypyrimidine tract-binding protein), which interacts with Nova-1 and inhibits its function [ 24 ] . DAZAP1 could function in a similar manner by binding to DAZL and inhibiting its function.
Our studies on nmt55 and those of p54 nrbhave characterized this protein as an RNA binding protein with the ability to associate with Topoisomerase I and the polypyrimidine tract-binding protein associated splicing factor (PSF) [ 16 17 18 19 20 ] . Further, we observed the association of nmt55/p54 nrbwith several splicing factors known to be essential for spliceosome formation suggesting a role for nmt55/p54 nrbin pre-mRNA splicing (unpublished results).
Our data suggests that nmt55/p54 nrbmay be critical to cell growth and function, such that, decreased nmt55/p54 nrbexpression in ER- human breast tumors or the expression of nmt55/p54 nrbvariants in ER+ tumors may indicate loss of normal growth, nmt55/p54 nrbhas been shown in several studies to bind RNA and interact with PSF and Topoisomerase I [ 14 16 17 18 19 20 39 ] . Those results along with our observations that nmt55/p54 nrbassociates with several splicing factors essential for spliceosome formation (unpublished) and relates to tumor hormonal status [ 13 ] suggest that nmt55/p54 nrbmay be involved in pre-mRNA processing.
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