Words similar to pre-m
Example sentences for: pre-m
How can you use “pre-m” in a sentence? Here are some example sentences to help you improve your vocabulary:
Null mutations in the single ADAR gene in Drosophila (dADAR) suggest that the function of pre-mRNA editing is to modify adult behavior by altering signaling components in the nervous system [ 25, 26].
RNA-binding proteins have been found to participate in many cellular functions, including RNA transcription, pre-mRNA processing, mRNA transport, localization, translation and stability [ 20 ] . A role for the DAZ family in the regulation of mRNA translation is supported by lines of circumstantial evidence, including the association of DAZL with polyribosomes [ 12 ] . The absence of DAZAP1 from polyribosomes indicates that it is not directly involved in protein synthesis.
Thus, loss of nmt55/p54 nrbprotein or the expression of nmt55/p54 nrbprotein variants in tumor cells may result in the loss of hERα expression, the expression of nonfunctional hERα or the altered expression other critical cell growth factors due to lack of proper pre-mRNA splicing.
It has been proposed that loss of hERα expression in breast tumors is the result of aberrant RNA processing [ 40 41 42 43 ] . These aberrantly spliced mRNAs, if translated, could lead to truncated receptors with hormone binding but not DNA binding function [ 44 ] . Further, there is evidence for the role of RNA processing in oncogenesis [ 45 46 ] . Many studies, including those on human hnRNP A2/B1 and the CD44 gene, suggest that high fidelity pre-mRNA splicing is critical to normal cellular function and may play a key role in oncogenesis and breast cancer progression [ 47 48 ] . The strong association between nmt55/p54 nrband hERα expression indicates that nmt55/p54 nrbmay be an important marker for breast cancer progression.
The methylation of arginine residues has been shown to take place in other pre-mRNA splicing proteins though the role of this modification is unknown [ 38 ] . One approach to determine the presence of a point mutation or a splice variant is to perform PCR coupled with sequencing techniques.
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