Words similar to pre-m
Example sentences for: pre-m
How can you use “pre-m” in a sentence? Here are some example sentences to help you improve your vocabulary:
It has been proposed that loss of hERα expression in breast tumors is the result of aberrant RNA processing [ 40 41 42 43 ] . These aberrantly spliced mRNAs, if translated, could lead to truncated receptors with hormone binding but not DNA binding function [ 44 ] . Further, there is evidence for the role of RNA processing in oncogenesis [ 45 46 ] . Many studies, including those on human hnRNP A2/B1 and the CD44 gene, suggest that high fidelity pre-mRNA splicing is critical to normal cellular function and may play a key role in oncogenesis and breast cancer progression [ 47 48 ] . The strong association between nmt55/p54 nrband hERα expression indicates that nmt55/p54 nrbmay be an important marker for breast cancer progression.
Nova-1 regulates the alternative splicing of the pre-mRNAs encoding neuronal inhibitory glycine receptor α2 (GlyR α2) [ 23 ] . The ability of Nova-1 to activate exon selection in neurons is antagonized by a second RNA-binding protein, brPTB (brain-enriched polypyrimidine tract-binding protein), which interacts with Nova-1 and inhibits its function [ 24 ] . DAZAP1 could function in a similar manner by binding to DAZL and inhibiting its function.
Group II introns were first identified in fungal mitochondria and grouped on the basis of their secondary structures [ 2 4 5 ] . They have been found in organelle genomes of fungi and plants and also in a number of bacteria [ 6 ] . None have been found in animals, although it has been suggested that group II introns may be progenitors of nuclear spliceosomal introns based on similarities between nuclear pre-mRNA splicing in eukaryotes and the splicing mechanism used by group II introns [ 7 8 ] .
However, this possibility contradicts current models of exon definition in which exons in pre-mRNA are first defined by proteins interacting across exons and then processed as relatively autonomous units.
This finding is not anomalous because analysis of exon sequences surrounding the total set of introns in S. cerevisiae pre-mRNA genes shows a preference for AAAG at the 5' splice site [ 31 ] . The final G in this motif has been established as significantly conserved in yeast [ 32 ] . The sequence at the proximal 5' exon region is required for interactions with the spliceosomal small nuclear ribonucleoprotein particle U1 [ 19 ] . Our data are, therefore, consistent with present understanding of yeast pre-mRNA splicing.
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