Words similar to pre-m
Example sentences for: pre-m
How can you use “pre-m” in a sentence? Here are some example sentences to help you improve your vocabulary:
RNA-binding proteins have been found to participate in many cellular functions, including RNA transcription, pre-mRNA processing, mRNA transport, localization, translation and stability [ 20 ] . A role for the DAZ family in the regulation of mRNA translation is supported by lines of circumstantial evidence, including the association of DAZL with polyribosomes [ 12 ] . The absence of DAZAP1 from polyribosomes indicates that it is not directly involved in protein synthesis.
Our data suggests that nmt55/p54 nrbmay be critical to cell growth and function, such that, decreased nmt55/p54 nrbexpression in ER- human breast tumors or the expression of nmt55/p54 nrbvariants in ER+ tumors may indicate loss of normal growth, nmt55/p54 nrbhas been shown in several studies to bind RNA and interact with PSF and Topoisomerase I [ 14 16 17 18 19 20 39 ] . Those results along with our observations that nmt55/p54 nrbassociates with several splicing factors essential for spliceosome formation (unpublished) and relates to tumor hormonal status [ 13 ] suggest that nmt55/p54 nrbmay be involved in pre-mRNA processing.
It has been proposed that loss of hERα expression in breast tumors is the result of aberrant RNA processing [ 40 41 42 43 ] . These aberrantly spliced mRNAs, if translated, could lead to truncated receptors with hormone binding but not DNA binding function [ 44 ] . Further, there is evidence for the role of RNA processing in oncogenesis [ 45 46 ] . Many studies, including those on human hnRNP A2/B1 and the CD44 gene, suggest that high fidelity pre-mRNA splicing is critical to normal cellular function and may play a key role in oncogenesis and breast cancer progression [ 47 48 ] . The strong association between nmt55/p54 nrband hERα expression indicates that nmt55/p54 nrbmay be an important marker for breast cancer progression.
This finding is not anomalous because analysis of exon sequences surrounding the total set of introns in S. cerevisiae pre-mRNA genes shows a preference for AAAG at the 5' splice site [ 31 ] . The final G in this motif has been established as significantly conserved in yeast [ 32 ] . The sequence at the proximal 5' exon region is required for interactions with the spliceosomal small nuclear ribonucleoprotein particle U1 [ 19 ] . Our data are, therefore, consistent with present understanding of yeast pre-mRNA splicing.
, MAG - R in pre-mRNA genes [ 13 ] ) need not be perfectly conserved in organisms but is rather a set of nucleotides that, with some statistical uncertainty, shows a non-random sequence pattern at sites flanking introns.
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