Words similar to pre-formed
Example sentences for: pre-formed
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Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that may play a role in several disease states, including arthritis, sepsis, Crohn's disease, allograft rejection, asthma and prostate cancer [ 1 2 3 ] . Although MIF was initially described as released from activated T-cells [ 4 5 ] , subsequent investigations have localized MIF in a variety of other cells and tissues (for a recent review [ 1 ] ). For example, pre-formed MIF stores can be found in the epithelia of several organs and may be released in response to endotoxemia [ 6 ] . The role of MIF in the central nervous system remains to be determined, yet neurons in the brain synthesize and rapidly release MIF while glial cells appear to store MIF [ 7 8 ] , and the anterior pituitary gland contains MIF that may be released during endotoxemia [ 9 ] .
The cover story explains that morality is no longer about a pre-formed set of abstract values.
In fibroblast models, inactivation of Rho causes retraction of pre-formed pseudopods with a resultant deposition of parallel tracks of thin dendritic processes [ 17 ] , a phenotype ultimately resembling that seen in C3 treated HPB-ALL.
Of interest, electroporation of C3 in conjunction with FITC-labeled monomers of actin did not demonstrate incorporation of FITC-actin in the altered pseudopods at early time points (data not shown), suggesting that the filamentous actin in the altered pseudopods initially results from rearrangement of pre-formed actin filaments.
The urothelium contains a rich store of pre-formed MIF [ 10 11 ] . Moreover, MIF protein and mRNA were also detected by Western blotting techniques and RT-PCR in the major pelvic ganglia (MPG) that provides efferent (parasympathetic and sympathetic) innervation to the bladder and other pelvic viscera [ 12 13 ] . In addition, the L6-S1 dorsal root ganglia (DRG) that provide afferent innervation to the bladder [ 13 ] and other pelvic viscera constitutively expressed MIF.
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