Example sentences for: ppar

How can you use “ppar” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It was reported that PPAR activation could down-regulate the activity of AP-1 by interfering with the functions of c-jun [ 36 37 ] . Therefore, the following set of experiments was designed to test if PPAR activation could reduce c-jun activation in 25-OH-cholesterol treated microglia.

  • PPAR agonists reduced the 25-OH-cholesterol induced c-jun activation and attenuated the cytotoxicity.

  • Based on the observations that: 1. cholesterol oxides cause PCD but the involvement of MAP kinases remains to be investigated; 2. PPARs are important in atherosclerosis but the effect of PPAR activation on cholesterol oxide induced PCD has not been determined, this study was designed to test if a dysregulation of MAP kinases was associated with the cholesterol oxide induced PCD, and to determine if PPAR activation could modulate the cholesterol oxide induced PCD.

  • Development of PPAR agonists that retain the antiatherogenic activity but dismiss the proatherogenic activities will be of great value [ 26 ] .

  • Cells were treated with 5 μM 25-OH-cholesterol together with PPAR agonists to be tested for 2 days, then the viability of each treatment was determined.


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