Words similar to ppar
Example sentences for: ppar
How can you use “ppar” in a sentence? Here are some example sentences to help you improve your vocabulary:
A recent study examined effects of PPARα-specific induction in murine livers using cDNA microarrays [ 30 ] . Despite the different strain of mice examined (C57BL/6J) and the different genomic technology utilized for the examination of differentially expressed genes (cDNA microarrays), several genes were found differentially regulated in both experiments, indicating that the PPAR agonist and LC-PUFA affect gene expression through similar pathways.
It was reported that PPAR activation could down-regulate the activity of AP-1 by interfering with the functions of c-jun [ 36 37 ] . Therefore, the following set of experiments was designed to test if PPAR activation could reduce c-jun activation in 25-OH-cholesterol treated microglia.
Since PPAR agonists appeared to reduce the c-jun activation caused by 25-OH-cholesterol treatment, the following experiment was designed to test if these agents could reduce 25-OH-cholesterol induced cytotoxicity.
Based on the observations that: 1. cholesterol oxides cause PCD but the involvement of MAP kinases remains to be investigated; 2. PPARs are important in atherosclerosis but the effect of PPAR activation on cholesterol oxide induced PCD has not been determined, this study was designed to test if a dysregulation of MAP kinases was associated with the cholesterol oxide induced PCD, and to determine if PPAR activation could modulate the cholesterol oxide induced PCD.
In spite of dramatic differences in the expression of a variety of PPAR-responsive genes, PPAR gene expression itself was quite constant in all mice analyzed, as previously reported [ 31 ] . This constancy of PPAR expression indicates that differences in the transcription of genes containing a PPRE are likely due to the direct activation of PPARs.
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