Words similar to postsynaptic
Example sentences for: postsynaptic
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Our interest in PKA and PKC activity in the NMJ derives from: (1) a report that RIα not only is enriched there, but also appears to be tethered to the postsynaptic membrane [ 19 ] , (2) the rich literature describing selective PKC isoform activity and functional compartmentalization in the NMJ and skeletal muscle, (3) our discoveries that D-AKAP1 and D-AKAP2 bind to and appear to colocalize with RIα, and often mitochondria [ 15 16 28 ] ; and (4) our finding that gravin binds to both PKA and PKC [ 13 ] .
Because RIα was observed in close association with the NMJ postsynaptic membrane [ 19 ] , we probed for D-AKAP expression and possible colocalization with this and other regulatory subunits.
PKA association with mitochondria has been well documented [ 38 39 40 41 42 ] . In mammalian sperm, it was found that nearly all RII-specific labeling was with mitochondria [ 43 ] . Furthermore, in bovine heart, PKA activity was detected in the matrix or the matrix side of the mitochondrial inner membrane [ 44 45 ] . However, the work of Halestrap and coworkers provided little evidence for intramitochondrial protein phosphorylation by PKA, but gave some evidence for outer membrane phosphorylation, both integral and loosely bound proteins [ 46 47 48 ] . The localization of RIIα to the postsynaptic region beyond the postsynaptic membrane is consistent with part of the immunostaining of NMJs in the soleus muscle [ 18 ] , yet differs in part because there is no overlap with the bungarotoxin label; however, this is in agreement with another study [ 17 ] .
However, while the presynaptically-derived choline released into the cytoplasm can be converted directly to ACh, the choline released by the postsynaptic cell must be initially taken up by the cholinergic nerve terminals.
Rhodamine-conjugated α-bungarotoxin was used to delineate the postsynaptic membrane of the NMJ because it binds tightly to the nAChR found at this membrane.
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