Words similar to postnatal
Example sentences for: postnatal
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The chimeric protein containing BMPR-IA was chosen because it has been previously reported that this is the predominant BMP receptor type expressed in embryonic and postnatal superior cervical ganglia (SCG) [ 29 ] . As indicated in Figure 5, follistatin and noggin significantly inhibit the dendrite promoting activity of BMP-5 in a concentration-dependent manner.
The postnatal rats were weaned at 21 days of age, and they attained sexual maturity during the 6th week of life.
Postnatal development
Recent experiments by Fults and colleagues support the idea that stabilized β-catenin expression in the postnatal CNS is not sufficient to initiate tumor formation [ 36 ] . Using the RCAS-TVA system they showed that overexpression of c-myc, but not of activated β-catenin, promoted the proliferation of neural progenitor cells in vivo and in vitro . In their in vivo experiments expression was initiated in nestin positive cells postnatally via injection of β-catenin stabilized by a point mutation in codon 37.
Wnt signaling is known to play a critical role in the development of the brain, and the midbrain and cerebellum do not form in animals lacking Wnt-1 [ 23 ] . Furthermore, targeted disruption of the frizzled-4 gene results in cerebellar abnormalities in mice [ 24 ] . Transgene expression from the PrP promoter is extremely low during embryonic development, with high-level postnatal expression largely restricted to neurons and glia of the CNS [ 25 ] . Transgenic mice expressing either wild-type or mutant β-catenin were generated so that a range of pathway activation could be examined.
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