Words similar to postnatal
Example sentences for: postnatal
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These TG mice showed progressive structural and functional abnormalities in their testes, leading eventually to infertility [ 23 24 25 ] . In our recent paper, we described an altered pattern of germ cell proliferation throughout postnatal life in the ABP-TG mice, resulting in a progressive reduction in total germ cell numbers with increasing age [ 26 ] . However, it was not clear whether the reduction in germ cell numbers was the result of a reduced rate of proliferation, an increased rate of apoptosis, or a combination of the two.
Macrophages are key angiogenesis effector cells that produce a number of growth factor stimulators and inhibitors, proteolytic enzymes and cytokines that can activate one or more steps in the angiogenesis cascade [ 15 16 17 ] . Recent studies have shown that angiopoietins promote postnatal neovascularization by potentiating angiogenic cytokines such as VEGF [ 9 10 ] .
Recent experiments by Fults and colleagues support the idea that stabilized β-catenin expression in the postnatal CNS is not sufficient to initiate tumor formation [ 36 ] . Using the RCAS-TVA system they showed that overexpression of c-myc, but not of activated β-catenin, promoted the proliferation of neural progenitor cells in vivo and in vitro . In their in vivo experiments expression was initiated in nestin positive cells postnatally via injection of β-catenin stabilized by a point mutation in codon 37.
Further studies of how CEP cells are released from bone marrow and to what extent they participate in postnatal angiogenesis will certainly provide valuable information regarding the therapeutic potential of CEP cells.
However, known neurotrophins are largely absent in the adult cochleae [ 4 ] and significant amounts of neurotrophin expression appear to develop only in postnatal animals in the CNS [ 24 ] . Such expression in the CNS could possibly offset to some extent the peripheral loss of neutrophins in targeted null mutants.
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