Words similar to polysomes
Example sentences for: polysomes
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Early studies indicated that depletion of amino acids and not other nutrients is essential for initiation of development [ 19 20 21 ] . Upon amino acid starvation, among other events there is a substantial decrease in the rate of initiation of protein synthesis, resulting in a reduction in size and amount of polysomes and accumulation of free ribosomes [ 19 22 23 ] . It is believed that the decrease in protein synthesis in response to starvation occurs post-transcriptionally, since adding back amino acids rapidly restores protein synthesis and does not require new mRNA synthesis [ 22 ] .
After 2 and 4 hours of development, cells were collected into polysome buffer (HMK-NP40 plus cycloheximide to stabilize the polysomes).
In Dictyostelium , a major shift in the polysome profile occurs as a result of starvation and initiation of development [ 19 23 ] . The percentage of mRNA associated with polysomes drops from about 80-90% in growing cells to 50-60% within several minutes of removal of the food source.
Although the initial decrease in translation is a result of a different mechanism, we conclude that phosphorylation of eIF2α by IfkA from about 1 to 7 hours after the onset of development results in a further decrease in overall translation initiation and thus in a secondary shift of polysomes to free ribosomes.
The previous cited results showed that the shift of ribosomes off of polysomes occurs earlier, and indeed we found that the shift occurred within both Ax4 and BS153 cells (table 1).
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