Words similar to polysomes
Example sentences for: polysomes
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. IfkA activation at these times results is a reduction in overall protein synthesis initiation as indicated by the secondary shift of polysomes to ribosomes.
Fractions 3 through 11 represent polysomes with decreasing numbers of associated ribosomes going from fraction 3 to fraction 11, while fractions 12 through 16 represent free ribosomes (fig.
For uninduced cells, only endogenous PP1α RNA can be found associated with polysomes (Figure 11, second lane).
Early studies indicated that depletion of amino acids and not other nutrients is essential for initiation of development [ 19 20 21 ] . Upon amino acid starvation, among other events there is a substantial decrease in the rate of initiation of protein synthesis, resulting in a reduction in size and amount of polysomes and accumulation of free ribosomes [ 19 22 23 ] . It is believed that the decrease in protein synthesis in response to starvation occurs post-transcriptionally, since adding back amino acids rapidly restores protein synthesis and does not require new mRNA synthesis [ 22 ] .
A very early event marking the initiation of development is a substantial reduction in overall translation initiation and a concomitant major shift of ribosomes from mRNA-associated ribosomes (polysomes) to free ribosomes [ 22 23 ] . The percentage of mRNA associated with polysomes drops from about 80-90% in growing cells to 50-60% within several minutes of the removal of the food source.
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