Words similar to polysaccharides
Example sentences for: polysaccharides
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Glycosaminoglycans (GAGs) are negatively charged polysaccharides derived from an amino hexose.
The protective effects of antibody to pneumococcal capsular polysaccharides have been appreciated since the development of serum therapy, in which passively transferred, serotype-specific antipneumococcal serum reduced mortality from pneumococcal pneumonia by half [1].
They include: (1) sulfate esters of polysaccharides {carrageenan [ 1 16 17 18 19 ] , cellulose sulfate [ 12 13 14 15 ] , and dextran or dextrin sulfate [ 1 2 3 4 5 6 7 8 9 10 11 ] }; (2) aryl sulfonates {poly(naphthalene sulfonate) [ 22 23 24 ] and poly(styrene-4-sulfonate) [ 20 21 ] }; and (3) aliphatic {Carbomer 974P/BufferGel [ 25 26 27 28 29 ] } and aromatic carboxylates {CAP [ 30 31 32 33 34 35 36 37 ] }. The anti-HIV-1 properties of these polymers are expected to depend on their complexation with virus proteins which is likely to occur mainly through the formation of salt linkages or ion pairs between oppositely charged groups on the polymers and virus proteins, respectively [ 56 ] . However, the anti-HIV-1 properties of these polymers may depend not only on their charge density, but also on the characteristics of their uncharged portions, which may be involved in hydrophobic and hydrogen bonding interactions which can elicit profound conformational changes in hydrophobic regions of proteins and cause disassembly of complex proteins consisting of subunits [ 57 ] . For these reasons it is not be expected that all anionic polymers, considered as anti-HIV-1 microbicides, would have similar biological activities.
Scorpion venom when injected exerts a strong inflammatory response [ 11 ] . Many plant species used against stings contain compounds with antiinflammatory properties, flavonoids (rutin, hesperidin, quercetin), coumarins (bergapten), coumestans (wedelolactone), triterpenes, sterols and saponins [ 38 11 ] . The mechanism of action of the flavonoids is based on the inhibition of enzymatic steps in the arachidonic acid cascade [ 38 ] . Plant compounds that are immunostimulants at very low doses are some alkaloids, quinones, isobutylamides, phenolcarboxylic acid esters and terpenoids [ 39 ] . Other plant compounds with immunostimulatory effects are sesquiterpene lactones [ 40 ] . Many polysaccharides and glycoproteins enhance the unspecific immune system by activating the phagocytotic activity of granulocytes and macrophages, or by inducing cytokine production or influencing complement factors [ 39 ] .
These polymers belong to several classes: (1) sulfate esters of polysaccharides (dextrin and dextran sulfates [ 1 2 3 4 5 6 7 8 9 10 11 ] ; cellulose sulfate [ 12 13 14 15 ] ; sulfate esters of galactose + 3,6-anhydrogalactose copolymers {carrageenan; [ 1 16 17 18 19 ] }); (2) polymers containing sulfonated benzene or naphthalene rings {poly(styrene-4-sulfonate) [ 20 21 ] } and naphthalene sulfonate polymers {PRO2000 [ 22 23 24 ] }; and (3) polycarboxylates (acrylic acid polymers {Carbomer 974P; BufferGel [ 25 26 27 28 29 ] }); and acetyl phthaloyl cellulose {cellulose acetate phthalate (CAP) [ 30 31 32 33 34 35 36 37 ] }.
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