Words similar to polyposis
Example sentences for: polyposis
How can you use “polyposis” in a sentence? Here are some example sentences to help you improve your vocabulary:
To date no studies or case reports have examined the use of aspirin in the treatment of FAP, although various clinical trials are under way [ 33 ] . In accordance with the above data, studies conducted in animals have always employed a prevention strategy as well [ 4 7 9 ] . To our knowledge, this is the first study to examine the therapeutic potential of aspirin in a rodent model of colon carcinogenesis, in particular, the Min /+ murine model of polyposis.
The Min /+ model has received great favour because it contains a mutation in the Apc gene, which is homologous to the human adenomatous polyposis coli (APC) gene [ 23 ] . Defects in the APC tumour suppressor gene are thought to play a role in greater than 70% of all colorectal cancers and is responsible for inherited syndromes of polyposis (FAP and Gardner's) [ 24 25 ] . Furthermore, in humans the majority of colorectal cancers arise from adenomatous polyps [ 26 ] .
The study revealed that treatment of Min /+ mice with established polyposis with aspirin for 4 weeks produce no appreciable therapeutic effect.
Polyposis in the Min /+ mouse differs slightly from the human condition of FAP.
The NSAID sulindac has been shown to cause regression of colorectal adenomas of patients with hereditary forms of polyposis (Familial Adenomatous Polyposis (FAP) and Gardner's Syndrome) [ 17 18 19 ] and in sporadic colorectal adenomas [ 20 ] . In addition, case reports have demonstrated that indomethacin and sulindac were effective co-therapy agents in the treatment of desmoid tumours [ 21 22 ] . Finally, the inclusion either of indomethacin, naproxen or sulindac in the chemotherapy regiment of gastric carcinoma patients resulted in a significant increase in survival; 30 months versus 6 months when NSAIDs included in treatment regime [ 22 ] .
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