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Example sentences for: pointes
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However, little is known about the mechanism responsible for these sex related differences in the QTc interval or in the occurrence of torsades de pointes.
Cardiac conduction disturbance has also been recognized in the mitochondrial cytopathy, Kearns-Sayre syndrome (Mendelian inheritance in Man database *530000), characterized as progressive external ophthalmoplegia and retinopathy [ 16 ] . Clinical manifestations of cardiac disease occur in 57% of patients with Kearns-Sayre syndrome [ 17 ] . The complete AV block in Kearns-Sayre syndrome may also be associated less commonly with ventricular tachycardia, torsade de pointes and ventricular fibrillation as the ultimate and often fatal stage of the condition [ 18 ] . However, to our knowledge, ventricular tachycardia as a presenting feature has not been described in the context of mitochondrial cytopathies in the neonatal period.
Furthermore, recent evidence suggested that women are more prone than men to develop torsades de pointes during administration of cardiovascular drugs that prolong cardiac repolarization [ 9 16 ] .
Hypokalemia and many types of electrocardiographic (ECG) abnormality are observed during the acute phase of subarachnoid hemorrhage (SAH) [ 1 2 3 ] . Among ECG abnormalities, a prolongation of the QT interval, especially when associated with hypokalemia, deserves particular attention because it is frequently observed in those patients who develop life-threatening ventricular arrhythmias such as tor-sades de pointes [ 1 2 4 ] . However, the pathogeneses of these abnormalities during the acute phase of SAH have not yet been fully investigated.
It was therefore impossible to consider the influence of QTc prolongation on the occurrence of critical cardiac arrhythmias such as torsades de pointes.
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