Example sentences for: plx

How can you use “plx” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Net1N(7m) contained mutations required to strongly inhibit Plx1-dependent disruption of Net1N-Cdc14 complexes, whereas Net1N(19m') contained additional mutations without compromising the affinity of Net1N to Cdc14 [ 25 ] . Both of these mutant proteins, when expressed in E. coli and assembled with recombinant Cdc14, were found to be severely defective in releasing Cdc14 upon treatment with Plx1 (data not shown).

  • To address this question, we tested the binding affinity of combinations of Plx1-phosphorylated or unphosphorylated Net1N and Cdc14.

  • Next, we asked if the mutant RENT complex is more resistant toward Plx1.

  • Indeed, Cdc5 and the Xenopus polo-like kinase Plx1 reduced the binding affinity between recombinant Cdc14 and Net1 by phosphorylating Net1, and dislodged both Cdc14 and Sir2 from the RENT complex in vitro .

  • Thus, the mutant RENT is at least 30-fold more resistant to Plx1 than wild-type RENT.

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