Example sentences for: pleckstrin

How can you use “pleckstrin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • PH, pleckstrin homology; PI3K, phosphoinositide 3-Kinase; SH2, Src homology-2, SH3, Src homology-3; XLA, X-linked agammaglobulinemia; xid ; x-linked immunodeficiency; TCR, T cell receptor; sIgM, surface immunoglobulin M; (GAP), GTPase-Activating Protein; GST, Glutathione S-Transferase; SDS, Sodium Dodecyl Sulfate; PBS, phosphate buffered saline; NP40, Nonidet P-40; PAGE, polyacrylamide gel electrophoresis.

  • These include SH3 domains (Src homology 3 domains, that bind to target proteins), MYTH4 (a domain of unknown function found in a few classes of myosins), a zinc-binding domain, a pleckstrin homology domain, FERM/talin (band 4.1/ezrin/radixin/moesin), GPA-rich domains and a protein kinase domain [ 8, 22, 26].

  • Thus, despite lacking a pleckstrin homology domain, Rlk is localized in RAFTs, is phosphorylated by Src family kinases, and may transduce signals downstream of Src family kinases during T cell activation.

  • Perhaps the most obvious of these differences is the lack of the pleckstrin homology domain in Rlk.

  • In the inactive state, the Rho-binding domain and the pleckstrin homology domain form an autoinhibitory loop by binding and blocking the kinase domain at the N-terminus of the molecule.


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