Words similar to plant-derived

Example sentences for: plant-derived

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Small-molecule modulators of growth-factor pathways have proven valuable in providing enhanced understanding of the intracellular events that occur subsequent to receptor activation, and in establishing the biological functions of these pathways [ 6 7 8 ] . In Hh signaling, multiple insights have been gained through the use of the plant-derived Hh antagonist cyclopamine [ 9 10 11 12 13 14 15 16 ] and a recently identified synthetic small-molecule Hh-signaling inhibitor, Cur61414 [ 17 ] . Interestingly, these specific inhibitors of Hh signaling appear to function downstream of Ptc but their precise molecular target(s) and mechanism of action are unknown.
The NR family contains two related ERs (ERα and ERβ) that conform to the typical three domain NR structure and share extensive sequence homology in the DBD and LBD region [ 20 21 ] . Analysis of the function of the individual ERs in mouse knockout models suggests that the major proliferative effects of estrogen are mediated by ERα and not by ERβ, which seems to play an inhibitory role in proliferation in some studies [ 22 23 ] . The ligand-binding properties of the ERs are different, with ERβ often exhibiting stronger binding to plant-derived phytoestrogens [ 24 ] . More importantly, the ERs exhibit isoform-specific effects on gene expression.