Example sentences for: penetrance

How can you use “penetrance” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The localization of genes in complex genetic diseases is a challenging proposition, given that these disorders are likely to show significant locus heterogeneity, genetic epistasis, and incomplete penetrance, as well as environmental effects.

  • Although the accelerated time course and high penetrance of disease reduces the costs of this model, it may be advisable to confirm efficacy of promising agents in a model that delays application of the chemopreventive agent until the mammary gland is fully developed.

  • Due to the probabilistic natureof the penetrance functions used to simulate the data,there is some degree of noise simulated in the data.

  • Assuming autosomal dominant inheritance with complete penetrance, two families (AG, E) are not linked and five families are inconsistent with linkage (AJ, AH, T, CT, BT) to the FEOM2 locus (see Additional File 3).

  • Penetrance is defined as the probability of diseasegiven a particular combination of genotypes.


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