Words similar to penetrance

Example sentences for: penetrance

How can you use “penetrance” in a sentence? Here are some example sentences to help you improve your vocabulary:

MAdCAM-1 is normally expressed in the gut, and its expression is dramatically amplified during inflammation [ 2 3 ] . The functional significance of increased appearance of MAdCAM-1 in IBD is supported by several reports which show that immunoneutralization of either MAdCAM-1 or its ligand, the α4β7 integrin, attenuate inflammation and mucosal damage in animal models of colitis [ 8 9 10 ] . However, since monoclonal antibodies directed against other ECAMs, particularly VCAM-1, can as well reduce disease activity in colitis models [ 11 12 13 14 ] , the literature suggests that MAdCAM-1 is probably necessary, but insufficient for the maximal penetrance of experimental and probably also clinical IBD.
This could be the result of variation in the penetrance of the mutation.
The binomial probabilities p 1 , p 2 , and p 3 represent the probability that a binary trait is present given a specific BTL genotype (GT), or the penetrance of the trait for the specific genotypes Q 1 / Q 1 , Q 1 / Q 2 , and Q 2 / Q 2 , respectively.
For this model, the high-risk genotypecombinations are AAbb , AaBb , and aaBB withdisease penetrance of 0.1, 0.05, and 0.1 respectively.
Genetic counseling for patients and family members should always accompany genetic testing as variable expressivity and age dependent penetrance may influence clinical decision making [ 25 ] .