Words similar to penciclovir

Example sentences for: penciclovir

How can you use “penciclovir” in a sentence? Here are some example sentences to help you improve your vocabulary:

Resistance to acyclovir (ACV) or penciclovir (PCV) generally arises by a single base mutation in either the HSV thymidine kinase (TK) or DNA polymerase (Pol) gene [for a review, see reference [ 5 ] ]. Unlike Pol, TK is not essential for virus replication in cell culture [ 7 ] , although in vivo analyses implicate it in HSV virulence, pathogenicity and reactivation from latency [ 4 8 16 22 ] . Since ACV and PCV are dependent upon HSV TK for monophosphorylation, an event obligatory for the formation of the active triphosphate inhibitor [ 14 ] , ACV risolates often exhibit high levels of cross-resistance to PCV [ 2 3 ] .
Thymidine kinase polypeptide (TK) is required for the activation of some antiviral nucleoside analogs e.g. acyclovir (ACV) and penciclovir (PCV), in order to inhibit viral DNA replication.