Words similar to pellucida
Example sentences for: pellucida
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When we tested the sera on three separate occasions with this method, we found 9 patient sera (35%) and 6 control sera (23%) to be consistently positive for zona pellucida antibody ( P = 0.38).
Sacco and Moghissi detected zona pellucida antibodies in both men and women by indirect immunofluorescence, but they used porcine rather than primate zonae pellicidae [ 27 ] . Normal animal and human serum are known to contain a wide range of low-titer autoantibodies that have been termed "natural autoantibodies" [ 28 ] . Even B cells from newborn mice and human cord blood produce these natural autoantibodies [ 29 30 31 ] . The low titer ovarian antibodies that we demonstrate here in the serum of normal women are likely natural autoantibodies, and not antibodies with any pathophysiologic significance.
These mice also develop autoimmunity against thyroid and gastric parietal cells [ 22 ] . It is well established that these mice with ovarian autoimmunity also develop circulating autoantibodies against the oocyte cytoplasm, the zona pellucida, and against steroid producing cells [ 22 ] . While we found evidence that one half of our patients had specific antibodies directed against the zona pellucida, we did not find any consistent pattern of immunofluorescence to suggest that our patients had antibodies directed against the oocyte cytoplasm or the steroid producing cells of the ovary.
Binding of antibody to the zona pellucida at a 1:10 dilution was reported by the laboratory on a scale of 0 to 3+ according to the intensity of fluorescence: 0, negative; 1+, weak; 2+ moderate or 3+ strong fluorescence (Figure 1).
To evaluate the reproducibility of the test we selected four patient samples previously determined by this technique to be 0, 1+, 2+, and 3+ for zona pellucida antibodies.
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