Example sentences for: pedigrees

How can you use “pedigrees” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In 127 multiplex SLE pedigrees, the best evidence for linkage was at D1S229, with the greatest extent of allele sharing in the white families at the D1S2616 marker.

  • Model-dependent linkage analysis has been used in large pedigrees with diseases such as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) [ 6 7 8 9 ] . However, traditional linkage analysis is unlikely to be the most expedient method of finding novel stroke-susceptibility genes when carrier status cannot be defined on the basis of distinctive clinical, radiographic, or laboratory features.

  • Genomic DNA extracted from blood was used to screen two affected family members from each of six previously described pedigrees [ 1, 2].

  • This CFEOM phenotype was first described in the medical literature in 1840 [ 9 ] and was recognized to occur as a familial trait in 1879 [ 10 ] . Subsequently, families segregating this phenotype have been published under myriad names [ 1 4 6 11 12 13 14 15 16 17 18 19 20 21 ] . We now refer to individuals with this phenotype as having "classic CFEOM" and to families in which all affected members have this phenotype as " CFEOM1 pedigrees".

  • The affected members of these pedigrees are born with bilateral ptosis and restrictive ophthalmoplegia.


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