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Example sentences for: parp
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PARP (110 kDa protein) was selected as a positive control to monitor the cleavage of proteins during apoptosis and necrosis because its cleavage products in Jurkat cells undergoing apoptosis (89 kDa) and undergoing necrosis (60 and 50 kDa) are well established [ 20 24 30 ] .
ADPRT = adenosine diphosphate ribosyltransferase; cM = centiMorgan; C-TDT = combined S-TDT and TDT; ESRRG = estrogen-related receptor gamma; HLA = human leukocyte antigen; kb = kilobasepairs; LOD = logarithm of odds ratio; MIM = Mendelian Inheritance in Man (database; see [ 1]); PARP = poly ADP ribosyl polymerase; PCR = polymerase chain reaction; PDT = pedigree disequilibrium test; SLE = systemic lupus erythematosus; S-TDT = discordant-sib TDT; TDT = transmission disequilibrium test; T:NT = ratio of transmitted to nontransmitted alleles.
AGA = anti-Golgi complex autoantibodies; H 2 O 2 = hydrogen peroxide; PARP = polyADP-ribose polymerase; PBS = phosphate-buffered saline; STS = staurosporine; zVAD-fmk = benzylocarbonyl-Val-Ala-Asp-fluromethylketone.
As with DFF45, PARP cleavage was significantly enhanced in BRCA1+ cells suggesting that decreased DNA repair capacity in BRCA1+ cells may, in part, be due to premature inactivation of PARP.
3, right), PARP was cleaved into an 89 kDa polypeptide (apoptotic fragments) or 60 and 50 kDa polypeptides (necrotic fragments), respectively, with complete degradation of native protein as previously described [ 24 ] . Golgin-160 was cleaved into 140 and 80 kDa fragments in apoptotic cells, consistent with published observations [ 29 ] . In contrast to the apoptotic fragments, a 70 kDa fragment was detected in necrotic cells.
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