Words similar to pannus
Example sentences for: pannus
How can you use “pannus” in a sentence? Here are some example sentences to help you improve your vocabulary:
In view of the analogies between erosion formation in arthritis and tumor invasion in cancer, we hypothesized that activated MMP-2 and possibly MMP-9 might play an important role in the early stages of invasion of synovial pannus into bone and cartilage.
Although there continues to be controversy regarding the origins of the invasive cells at the junction of cartilage/bone and pannus, considerable evidence has accumulated that the lining cells in RA synovium exhibit a 'transformed' phenotype that is typical of invasive cells [ 26, 48].
In addition members of this subfamily of MMPs are involved in the invasiveness of cancers [ 15, 16], and thus may also play a similar role in the invasion of synovial pannus.
Although both of these MMPs are expressed at the junction between synovial pannus and cartilage or bone [ 14], further evidence of their direct role in erosion formation is lacking.
The antigen-induced arthritis model of rheumatoid arthritis in rabbits demonstrates persistent active inflammation for several months after the intra-articular injection of antigen, including hypertrophy and hyperplasia of the synovial lining cells, pannus formation with articular cartilage erosion, and chronic infiltration of synovium by lymphocytes and plasma cells [ 13 ] . In addition, Dijkstra and colleagues [ 15 ] found macrophages in the superficial layer of the synovium, where they might secrete enzymes and oxygen radicals into the joint space, which can lead to cartilage erosion [ 9 ] . The protein levels in lavage fluid from arthritic joints in this model are low enough to allow direct testing by Western blot analysis without immunoaffinity purification, as was needed with the human aspirates.
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