Words similar to paclitaxel-resistant
Example sentences for: paclitaxel-resistant
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In other work, β-tubulin classes III and IVa were shown to increase in paclitaxel-resistant prostate cancer cells [ 29 ] . However, these two isotypes continued to be expressed in the lowest amounts.
For example, total amounts of polymerizable tubulin are decreased in paclitaxel-resistant cells, whereas col-cemid-resistant tubulin or vinca alkaloid-resistant cells have increased levels of assembled tubulin [ 34 66 67 ] . Furthermore, when cells were transfected with β-tubulin class III, weak resistance to paclitaxel was found, and this resistance was associated with decreased microtubule stability [ 68 ] . This is consistent with the different modes of action of these drugs: paclitaxel stabilizes microtubules and colcemid inhibits tubulin assembly.
In support of this hypothesis, tubulin mutations consistent with altered assembly properties have been identified in paclitaxel-resistant and vinca alkaloid-resistant cells [ 33 66 69 ] .
In ovarian cancer cells, mutations in residues near the putative paclitaxel-binding site of β-tubulin class I were found in paclitaxel-resistant ovarian cancer cells [ 23 ] . Other work suggests that changes in tubulin isotypes alone cannot confer resistance to antimitotics.
For example, paclitaxel-resistant lung cancer cells and ovarian tumors were shown to have increased levels of tubulin isotypes, particularly β-tubulin classes III and IVa [ 28 ] . Furthermore, when paclitaxel-resistant lung cancer cells were treated with antisense oligonucleotides for β-tubulin class III, the drug resistance was partly reversed, coincident with decreased protein levels of β-tubulin class III [ 65 ] . However, it should be noted that β-tubulin classes I, II, III, and IVa all increased significantly in paclitaxel-resistant lung cancer cells, indicating that the drug effect did not uniquely involve a single tubulin isotype.
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