Example sentences for: overload

How can you use “overload” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These patients may have coexisting total body volume overload and intravascular volume depletion.

  • It has been hypothesized that the high prevalence of negative school behaviors is in part due to greater exposure to chronic psychosocial stress, e.g., inadequate economic resources, family disintegration, information overload, media violence [ 8 9 10 11 ] . Self-reported feelings of anger have been shown to be predictive of aggression in youth [ 12 ] . The escalating prevalence of anger and violence in youth has been associated in part with increased levels of anxiety and stress [ 13 ] .

  • The first, the ER overload response, triggers the activation of the transcription factor NFkB and the subsequent upregulation of inflammatory proteins [ 13 ] . The second, the unfolded protein response (UPR) induces three divergent cellular events: (i) the activation of transcription factor ATF6 leading to the upregulation of ER chaperones such as protein disulfide isomerase, (ii) upregulation of the pro-apoptotic transcription factor GADD153 and (iii) suppression of protein synthesis via phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) by pancreatic eIF2α kinase (PEK/PERK, [ 11 12 ] ). Upregulation of the ER chaperones, GADD153 and PERK in response to a toxic insult would constitute direct evidence of an ER stress response.

  • Iron deficiency has also been shown to lead to ventricular hypertrophy in developing rats [ 11 12 13 14 15 16 17 ] . While the mechanisms responsible for this hypertrophy have received little research attention, studies have documented an eccentric hypertrophic pattern [ 15 16 17 ] which has led investigators to suspect a ventricular volume overload at end diastole as a primary hypertrophic stimulus.

  • Iron overload was detected using serum ferritin concentration, hepatic iron index, or quantitative phlebotomy in 135 probands; three women and one man had no evidence of iron overload.

How many words do you know? Try our free vocabulary size test!


Search for example sentences

Loading Loading...