Example sentences for: overload

How can you use “overload” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Cardiomyopathy attributable to iron overload was not diagnosed in any proband.

  • It has been hypothesized that the high prevalence of negative school behaviors is in part due to greater exposure to chronic psychosocial stress, e.g., inadequate economic resources, family disintegration, information overload, media violence [ 8 9 10 11 ] . Self-reported feelings of anger have been shown to be predictive of aggression in youth [ 12 ] . The escalating prevalence of anger and violence in youth has been associated in part with increased levels of anxiety and stress [ 13 ] .

  • The first, the ER overload response, triggers the activation of the transcription factor NFkB and the subsequent upregulation of inflammatory proteins [ 13 ] . The second, the unfolded protein response (UPR) induces three divergent cellular events: (i) the activation of transcription factor ATF6 leading to the upregulation of ER chaperones such as protein disulfide isomerase, (ii) upregulation of the pro-apoptotic transcription factor GADD153 and (iii) suppression of protein synthesis via phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) by pancreatic eIF2α kinase (PEK/PERK, [ 11 12 ] ). Upregulation of the ER chaperones, GADD153 and PERK in response to a toxic insult would constitute direct evidence of an ER stress response.

  • A presumptive diagnosis of hemochromatosis was established using an elevated transferrin saturation criterion; each proband was subsequently evaluated for iron overload and its complications [ 21 22 23 ] . All probands in the present study were white adults (> 18 years of age).

  • If you have the time, try to visit St. Peter’s Basilica and the Vatican Museums on separate days to avoid fatigue and visual overload.


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