Words similar to overdominance
Example sentences for: overdominance
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Existing data suggest that allele-specific overdominance may exist in some animal infectious diseases, but also that simple dominance and other outcomes are commonly observed [ 11 ] . Several experimental studies have examined this question using single-strain infections in animals, and while suggestions of allele-specific overdominance have been made, none of the studies has been entirely convincing.
We have shown that when allele-specific overdominance exists, it will often be manifest as population heterozygote advantage, but that a finding of population heterozygote advantage may be consistent with other patterns of allele-specific effects; for example, when resistant and susceptible alleles are equally common and equally diverse, population heterozygote advantage will occur if allele-specific effects are additive, dominant or overdominant.
Although population heterozygote advantage and allele-specific overdominance are different [ 10 ] , reports of population heterozygote advantage have frequently been interpreted as confirmations of the Doherty-Zinkernagel hypothesis of allele-specific overdominance.
As noted by Doherty and Zinkernagel [ 4 ] , simple dominance for resistance to each of several diseases can create allele-specific overdominance for total fitness, if different alleles confer resistance to different diseases [ 10 31 ] . For these reasons, our results, while relevant to the longstanding debate over the relative importance of various kinds of balancing selection in maintaining MHC diversity [ 32 ] , raise doubts about only one of several lines of evidence for the overdominance hypothesis.
Figure 1shows that allele-specific overdominance (the biological phenomenon of interest) and population heterozygote advantage (the finding of epidemiological studies such as those cited above) are two different things.
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