Example sentences for: overdominance

How can you use “overdominance” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • That is, even when allele-specific overdominance holds, it is possible that heterozygotes on average will do worse than homozygotes, so population heterozygote advantage will not be observed.

  • Although neither population heterozygote advantage nor allele-specific overdominance implies the other, the two phenomena are of course related.

  • Specifically, the conditions to observe population heterozygote advantage are broadest when allele-specific overdominance holds and become narrower as the underlying genetics becomes more "different" from overdominance of resistance (dominance -> additivity -> recessiveness -> underdominance).

  • As noted by Doherty and Zinkernagel [ 4 ] , simple dominance for resistance to each of several diseases can create allele-specific overdominance for total fitness, if different alleles confer resistance to different diseases [ 10 31 ] . For these reasons, our results, while relevant to the longstanding debate over the relative importance of various kinds of balancing selection in maintaining MHC diversity [ 32 ] , raise doubts about only one of several lines of evidence for the overdominance hypothesis.

  • We show that, depending on allele frequencies at the HLA locus of interest, population heterozygote advantage may occur when there is allele-specific overdominance, but may also occur under other conditions, including allele-specific underdominance.


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