Example sentences for: overdominance

How can you use “overdominance” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We have shown that when allele-specific overdominance exists, it will often be manifest as population heterozygote advantage, but that a finding of population heterozygote advantage may be consistent with other patterns of allele-specific effects; for example, when resistant and susceptible alleles are equally common and equally diverse, population heterozygote advantage will occur if allele-specific effects are additive, dominant or overdominant.

  • Because these studies group all homozygotes and group all heterozygotes, they do not, in fact, test the hypothesis of allele-specific overdominance, which is conditional on the alleles involved.

  • That is, even when allele-specific overdominance holds, it is possible that heterozygotes on average will do worse than homozygotes, so population heterozygote advantage will not be observed.

  • Although neither population heterozygote advantage nor allele-specific overdominance implies the other, the two phenomena are of course related.

  • Our results do not deny that allele-specific overdominance at HLA exists in human populations with respect to infectious disease resistance, but simply raise doubts about the reliability of the major evidence that has been adduced in support of this phenomenon.


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