Words similar to overdominance
Example sentences for: overdominance
How can you use “overdominance” in a sentence? Here are some example sentences to help you improve your vocabulary:
Figure 1shows that allele-specific overdominance (the biological phenomenon of interest) and population heterozygote advantage (the finding of epidemiological studies such as those cited above) are two different things.
From the perspective of the population genetics debate concerning the role of overdominance in maintaining polymorphism at the MHC, we should note that this mechanism requires allele-specific overdominance for total fitness, not for resistance to individual diseases.
As an alternative to directly examining the hypothesis of allele-specific overdominance, several investigators have compared the infectious disease outcomes of heterozygotes at a given HLA locus, as a group, to the outcomes of homozygotes at the same locus, as a group.
Our results do not deny that allele-specific overdominance at HLA exists in human populations with respect to infectious disease resistance, but simply raise doubts about the reliability of the major evidence that has been adduced in support of this phenomenon.
Moreover, direct estimates of the allele-specific effects of heterozygosity (relative to the corresponding homozygotes), nearly absent in the infectious disease-HLA literature, are frequently found in studies of HLA genotype and chronic (mostly autoimmune) diseases [ 28 29 30 ] . We do not know the reason for this difference in approach, but suspect that some infectious disease investigators, informed by the evolutionary hypothesis of overdominance for infectious disease resistance and by animal studies, may have a special interest in detecting effects of heterozygosity per se . Many studies of HLA-autoimmune disease associations, on the other hand, seem to focus more on the effects of individual alleles and, having established these, move on to investigate the dependence of these effects on genetic modifiers, including the identity of the individual's other allele at the same locus.
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