Example sentences for: overdominance

How can you use “overdominance” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • As we have suggested above, it is biologically and epidemiologically useful to determine (a) the beneficial or harmful effects of specific alleles, and (b) the effects of heterozygosity, such as allele-specific overdominance; we show here that unconditional comparisons of all heterozygotes to all homozygotes can reflect either or both of these, and cannot distinguish them.

  • In this situation, population heterozygote advantage does not require overdominance, but merely allele effects that are more than additive (partial dominance).

  • Figure 1shows that allele-specific overdominance (the biological phenomenon of interest) and population heterozygote advantage (the finding of epidemiological studies such as those cited above) are two different things.

  • Specifically, the conditions to observe population heterozygote advantage are broadest when allele-specific overdominance holds and become narrower as the underlying genetics becomes more "different" from overdominance of resistance (dominance -> additivity -> recessiveness -> underdominance).

  • We have shown that when allele-specific overdominance exists, it will often be manifest as population heterozygote advantage, but that a finding of population heterozygote advantage may be consistent with other patterns of allele-specific effects; for example, when resistant and susceptible alleles are equally common and equally diverse, population heterozygote advantage will occur if allele-specific effects are additive, dominant or overdominant.


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