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Example sentences for: oric
How can you use “oric” in a sentence? Here are some example sentences to help you improve your vocabulary:
Likewise, the oriC region in M. paratuberculosis was found to share a high level of nucleotide identity (~98%) with M. avium . Calculation of the rates of total nucleotide diversity (3) and synonymous substitution per synonymous site (ds) and non-synonymous substitution per non-synonymous site (dn) revealed patterns of variation within the range observed from sequence data outside the oriC region.
We next determined if the nucleotide identities would remain consistently high when M. paratuberculosis sequences outside the oriC region were compared with M. avium . Sequencing of the M. paratuberculosis K-10 cattle isolate is nearing completion in our laboratories and TIGR http://www.tigr.orgis in the finishing stages of M. avium isolate 104.
The sequence immediately flanking the dnaA gene is considered the origin of chromosomal replication, or oriC region [ 9 10 ] . This region contains several genes that encode proteins required for basic cellular functions, including the protein subunit of RNase P (RnpA), ribosomal protein L34 (RpmH), the replication initiator protein (DnaA), the beta subunit of DNA polymerase III (DnaN), the recombination repair protein RecF, and the DNA gyrase proteins GyrA and GyrB.
The oriC of Gram-positive bacteria typically contains 10 - 30 of these DnaA boxes, often found in non-coding regions flanking the dnaA gene.
Because of strong similarity in the oriC region, alternative hypotheses should be tested to explain the growth rate differences between M. avium and M. paratuberculosis . Genomic rearrangements and the presence of unique genes identified by matrix analysis in this study are two such possibilities that could account for some of the phenotypic differences.
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