Example sentences for: orbitofrontal

How can you use “orbitofrontal” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In addition, it had also become clear that lesions to the orbitofrontal cortex were associated with impairments in emotional and social behaviour, characterised by disinhibition, social inappropriateness, and irresponsibility (Anderson et al.

  • We used functional magnetic resonance imaging to show that the ability to change behaviour based on facial expression is not reflected in the activity of the fusiform face area (which invariably appears to reflect only identity and not valence), but that general reversal learning is specifically correlated with activity in the lateral orbitofrontal and anterior cingulate/paracingulate cortices (as well as other brain areas, including the ventral striatum and the inferior precentral sulcus) (Kringelbach and Rolls 2003).

  • One study demonstrated that single neurons in the macaque orbitofrontal cortex change their responses to a visual cue after a single trial in which the reward association of the visual cue is reversed (Thorpe et al.

  • There was also some evidence that humans with lesions to the orbitofrontal cortex have problems with reversal learning, but the lesions, caused by neurological insult, were not very clean or focal (Rolls et al.

  • Further confirmation came from the neuropsychological testing, carried out by Julia Hornak on human patients with surgical lesions to the orbitofrontal cortex, which showed that bilateral (but not unilateral) lesions to the lateral orbitofrontal cortex produce significant impairments in reversal learning (Hornak et al.


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