Words similar to opn
Example sentences for: opn
How can you use “opn” in a sentence? Here are some example sentences to help you improve your vocabulary:
Synthesis of OPN was also observed in infiltrating lymphocytes and macrophages, a factor that would seriously compromise efforts to quantify OPN in homogenized tissue specimens.
But it is possible that in vitro OPN expression is a phenomenon of cell culture or that OPN-positive cells have a selective growth advantage during extended passage.
OPN is a secreted glycophosphoprotein expressed by a number of cell types, including leukocytes and epithelial lineages, and it has been implicated biologically in bone development, in immune system regulation [ 6 ] , and in multiple mechanisms through signal transduction via its binding to integrins [ 7 ] . OPN has been detected in primary breast tumors and is elevated in the plasma of patients with metastatic breast cancer [ 8 9 ] , but an association between elevated levels of primary tumor OPN and metastatic burden has not been well established.
Our LCM-mediated transcript detection acts as an important confirmation of breast tumor cell OPN synthesis because IHC analysis does not rule out the possibility that secreted proteins such as OPN and TSP-1 are sequestered by the tumor cells from the local environment.
TSP-1 is a homotrimeric multidomain glycoprotein synthesized and secreted by numerous cell types, including platelets, vascular smooth muscle cells and keratinocytes [ 4 ] . Due to its interaction with a wide variety of proteins, TSP-1 has been implicated in a number of biological processes including coagulation, cell adhesion, the modulation of cell-cell and cell-matrix interactions, control of tumor growth and metastasis, and angiogenesis [ 10 ] . Inhibition of tumor cell proliferation has been achieved in vivo by systemic treatment with TSP-1 peptide mimetics [ 11 ] , but a correlation between primary tumor TSP-1 expression and poor prognosis has not been clearly established [ 12 ] . While there are reports that these molecules can originate from tumor cells [ 13 ] , the majority of reports have suggested that the major source of both TSP-1 and OPN is tumor-associated stroma [ 14 ] or infiltrating macrophages and lymphocytes [ 15 ] .
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