Words similar to opn

Example sentences for: opn

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The sequences of the PCR primer pairs used for each gene are as follows: TYRP-1, 5'-GATGGCAGAGATGATCGGGA-3' and 5'-AGAAATTGCCGTTGCAGTGAC-3' ; TSP-1, 5'-CAGCAGCCGCTTTTATGT-3' and 5'-CCGAGTATCCCT-GAGCCCTC-3' ; OPN, 5'-TTGCAGCCTTCTCAGCCAA-3' and 5'-GGAGGCAAAAGCAAATCACTG-3' ; and GAPDH, 5'-CCACCCATGGCAAATTCC-3' and 5'-GGGATTTCCATTGATGACA-3'.
OPN is a secreted glycophosphoprotein expressed by a number of cell types, including leukocytes and epithelial lineages, and it has been implicated biologically in bone development, in immune system regulation [ 6 ] , and in multiple mechanisms through signal transduction via its binding to integrins [ 7 ] . OPN has been detected in primary breast tumors and is elevated in the plasma of patients with metastatic breast cancer [ 8 9 ] , but an association between elevated levels of primary tumor OPN and metastatic burden has not been well established.
Elevated levels of OPN and TSP-1 expression in primary and metastatic carcinomas suggest that these genes may be necessary for, but not sufficient for, dissemination.
TYRP-1 expression was higher than that of TSP-1 but lower than that of OPN (10-fold to 50-fold).
Nor was there a quantitative difference in OPN expression between primary carcinomas and matched metastases (Fig.