Words similar to opn

Example sentences for: opn

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Overall, the degree and intensity of OPN expression was qualitatively equal in samples of adenomas, adenocarcinomas and nodal metastases from patients with disseminated disease.
By applying in situ hybridization, Tuck and colleagues identified breast tumor cells as a source of OPN [ 13 ] . Using a semiquantitative scoring system to evaluate immunohistochemical staining, these investigators found a correlation between OPN positivity (defined as >33% of tumor cells in a section staining for OPN) in lymph node-negative primary breast carcinomas and patient survival, suggesting that tumor cells with elevated OPN levels may behave differently with regard to disease progression [ 13 ] . Another recent study showed immunohistochemically that while OPN protein is expressed weakly in normal breast tissue, OPN is expressed strongly (>50% tumor cell staining) in pregnant/lactating tissue and in the majority (66%) of breast carcinomas.
Immunohistochemical detection of OPN, TSP-1 and TYRP-1 in human breast tissues
The presence of OPN in inflammatory cells highlights the advantage of microdissection in this analytical context.
We have demonstrated that human breast epithelia can themselves synthesize OPN and, to a lesser extent, TSP-1 and TYRP-1 in vivo , and that elevated OPN and TSP-1 levels are indicative of malignancy.