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Example sentences for: oogonia
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Fluorescence measurements of immunostained oogonia/oocytes
In fact, the apoptotic demise (yielding double-stranded DNA breaks) of female germ cells throughout gestations of most vertebrates will encompass more than one-half of precursor populations [ 38 39 ] . Day 75 is the approximate time-point when a maximum number of oogonia is achieved in lambs; a nearly five-fold loss then occurs between Days 75 and 90 [ 40 ] . In some cases of nutritional deprivation cellular losses are accelerated [ 38 ] and reproductive performance of the female offspring during adulthood is attenuated [ 1 ] . Prenatal exposure to famine (1944-45 Dutch cohort) did not affect subsequent fertility of women [ 41 ] . Numbers of oogonia/oocytes and weights of mid-gestational fetal ovaries of sheep were increased [ 2 42 ] or not influenced by undernutrition [ [ 3 ] , present study].
Results of this study indicate that in underfed ewes p53, Bcl-2, and polymerase β are up-regulated in fetal oogonia containing elevated contents of 8-oxoguanine.
, leakage of radicals associated with the reduction of oxygen to water during mitochondrial respiration) [ 34 ] . The etiological basis for the formation of abnormally high levels of 8-oxoguanine adducts in oogonia of lambs of undernourished ewes is unknown.
In conclusion, we surmise that oxidative base damages to the DNA of fetal oogonia of pregnant animals faced with a nutritional adversity are a potential threat to the genetic character and reproductive capacity of their progeny; the predicament can evidently be reconciled by response mechanisms of cell-cycle arrest, survival, and repair.
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