Words similar to olanzapine
Example sentences for: olanzapine
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The integrated EMG recorded during the end of the bladder contraction (Phase 3) was also decreased by both neuroleptics, with olanzapine reducing it to 69% and 35% at 0.1 and 1.0 mg/kg, respectively, whereas the maximal effect for risperidone was observed at 1 mg/kg (68%).
In this study olanzapine had greater effects than risperidone but both decreased micturition volume and increased residual volume in anesthetized rats.
Clozapine is a widely used atypical neuroleptic with affinity for multiple receptors, including dopamine, serotonin, alpha adrenergic, muscarinic and histaminergic receptors [ 1 2 ] . Although clozapine is effective in the treatment of schizophrenia refractory to traditional antipsychotic medication, it also has a number of significant side effects ranging from the potentially fatal but rare agranulocytosis to weight gain, constipation, seizures and urinary incontinence [ 3 ] . Urinary problems have been reported in the clinical literature with incontinence present in up to 44% of patients [ 4 ] and enuresis in 27% of patients [ 5 ] . Since clozapine has potent anti-muscarinic and anti-alpha adrenergic effects [ 2 ] , it has been proposed that peripheral effects on the lower urinary tract might be responsible for the micturition disturbances [ 6 ] . Incontinence has also been reported following therapy with other atypical neuroleptics such as risperidone [ 7 8 9 ] and recently, olanzapine [ 10 ] .
Effects of olanzapine and risperidone on single cystometry parameters (Tables 2and 3)
Clinically effective doses of olanzapine (10-15 mg/day; 18.
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