Words similar to okadaic

Example sentences for: okadaic

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Nonetheless, it is clear that PP5 is sensitive to inhibition by okadaic acid at the concentrations that also affects the activity of PP1 and PP2A.
However, as seen in Figure 1, the dephosphorylation of phosphohistone by the catalytic subunit of purified PP5 from bovine brain is also potently inhibited by okadaic acid.
Inhibition of phosphatase activity by okadaic acid was determined by adding the inhibitors to the enzyme mixture 10 minutes prior to initiating the reaction with the addition of substrate.
To inhibit any endogenous PP2A activity, which can also dephosphorylate phosphorylase a and thus interfere with PP1 activity measurements, these assays were carried out in the presence of 5 nM okadaic acid, which does not inhibit PP1 activity [ 30 ] . Although reproducible, we observed only modest increases in PP1-specific activity found in lysates from induced cells compared to the uninduced controls (Figure 7).
Recent studies with okadaic acid suggest phosphorylation alters the high affinity binding of GR to hsp-90, and that an intact cytoskeleton is required for ligand-activated GR translocation through the cytoplasm to the nucleus [ 8].