Words similar to ogg
Example sentences for: ogg
How can you use “ogg” in a sentence? Here are some example sentences to help you improve your vocabulary:
They were also scored for Ogg1 positive islet area as follows: 0; no or very small area of the islet stained for Ogg1; 25, approximately 25% of the islet area was Ogg1 positive; 50, approximately 50%; 75, approximately 75%; and 100, approximately 100%.
The pancreatic islets were evaluated blindly with semi-quantitative morphological scoring of fluorescent intensity: 0, no or very weak Ogg1 staining; 1, moderate Ogg1 staining; and 2, strong Ogg1 staining.
However, as we also detected a significant increase in the islet area stained for Ogg1, we are confident that islet cell Ogg1 is actually upregulated in type 2 diabetes.
Unfortunately, there have been no studies of the effects of long-term chronic increases in oxidative DNA damage on Ogg1 expression.
Ogg1 knockout mice possess increased levels of 8-OH-dG in their genome, particularly in the mitochondrial genome, but do not seem to exhibit an increased frequency of malignancies [ 44 45 46 ] . It was postulated that the consequences of 8-OH-dG adducts and Ogg1 deficiency affects mainly cells with high oxygen metabolism and slow proliferation, such as liver cells [ 45 ] . While β-cells were not examined in that study, they certainly exhibit both high oxidative metabolism and a low rate of proliferation, consistent with them being a target for the effects of 8-OH-dG adducts.
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