Words similar to ogg
Example sentences for: ogg
How can you use “ogg” in a sentence? Here are some example sentences to help you improve your vocabulary:
The promoter of the Ogg1 gene does not have a TATA box [ 40 ] , but Ogg1 is differentially expressed in the rat CNS, and its expression is increased after mouse forebrain ischemia-reperfusion [ 35 36 ] , suggesting that regulation occurs, either at the transcriptional or post-transcriptional level.
By semi-quantitative scoring, both the intensity and the area of Ogg1 staining were significantly increased (P < 0.05 and P < 0.02, respectively) in islets from the type 2 diabetic subjects compared to the healthy controls (Fig.
βOgg1 is an alternatively spliced form of Ogg1 that contains a mitochondrial targeting signal in the C-terminal portion of the protein [ 41 ] . Specific upregulation of mitochondrial but not nuclear Ogg1 occurs during aging in rodents [ 42 ] . A specific increase of Ogg1 in islet cell mitochondria is consistent with the idea that increased β-cell mitochondrial oxidative metabolism due to hyperglycemia is a major factor behind the DNA damage.
Ogg1 knockout mice possess increased levels of 8-OH-dG in their genome, particularly in the mitochondrial genome, but do not seem to exhibit an increased frequency of malignancies [ 44 45 46 ] . It was postulated that the consequences of 8-OH-dG adducts and Ogg1 deficiency affects mainly cells with high oxygen metabolism and slow proliferation, such as liver cells [ 45 ] . While β-cells were not examined in that study, they certainly exhibit both high oxidative metabolism and a low rate of proliferation, consistent with them being a target for the effects of 8-OH-dG adducts.
Increases in Ogg1 activity and expression have been found by a number of investigators [ 35 36 37 ] . Although antibodies to 8-OH-dG exist [ 38 ] , Ogg1 was used as a surrogate for the amount of oxidative DNA damage.
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