Words similar to og-fe

Example sentences for: og-fe

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Before this study, structure determination, biochemical studies and sequence comparisons of 2OG-Fe(II) dioxygenases [ 1, 9] had elucidated their structural fold, active-site residues and reaction mechanism.
The classic AraC-like DSBH proteins appear to have a more universal distribution than the 2OG-Fe(II) dioxygenases, with diverse forms represented in archaea, bacteria and eukaryotes.
On the basis of the results of database searches with representative sequences, we delineated several distinct families within the 2OG-Fe(II) dioxygenase fold and constructed individual alignments for each using the ClustalW program [ 24].
This, together with the phyletic distributution of the AraC and 2OG-Fe(II) dioxygenase superfamilies, leads us to speculate that the 2OG-Fe(II) dioxygenase superfamily evolved from the AraC-like superfamily in bacteria through drastic sequence divergence that eliminated significant sequence similarity, followed by fixation of the modified active-site configuration.
Despite the lack of detectable sequence similarity to 2OG-Fe(II) dioxygenases, these proteins contain a conserved HXH motif and a carboxy-terminal histidine that appear to be equivalent to the metal-chelating HXD and carboxy-terminal histidine of the latter (see above).