Words similar to og-fe
Example sentences for: og-fe
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Sequence conservation is high within individual families of the 2OG-Fe(II) dioxygenase superfamily, with specific extensions typical of each family, but low between different families (Figure 1).
Despite the lack of detectable sequence similarity to 2OG-Fe(II) dioxygenases, these proteins contain a conserved HXH motif and a carboxy-terminal histidine that appear to be equivalent to the metal-chelating HXD and carboxy-terminal histidine of the latter (see above).
The classic AraC-like DSBH proteins appear to have a more universal distribution than the 2OG-Fe(II) dioxygenases, with diverse forms represented in archaea, bacteria and eukaryotes.
The predicted 2OG-Fe(II) dioxygenase activity of AlkB is probably involved in the detoxification of methylated bases in ssDNA, possibly through hydroxylation of the methyl groups, resulting in less toxic base derivatives.
Fortuitously, these latter alkane hydroxylases are also oxygenases; however, they are not 2OG-Fe(II) dioxygenases but a distinct class of di-iron enzymes [ 23].
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