Words similar to odc
Example sentences for: odc
How can you use “odc” in a sentence? Here are some example sentences to help you improve your vocabulary:
The best-characterized example of ubiquitin-independent degradation is the degradation of ornithine decarboxylase (ODC), which is dependent upon ODC interaction with the targeting protein antizyme (Az) [ 18 ] . How ubiquitinated substrates or Az-bound ODC is recognized by the 26S proteasome is not well understood.
2. The human ABCG5 and ABCG8 genes are present in a group of 18 genes ABCG5, ABCG8, SLC8A1, PRKR, GCKR, KHK, PPP1CB, APOB, POMC1, SDC1, MYCN, DDX1, VSNL1, RRM2, ODC1, ID2, TPO and ACP1 in the region HSA2p21-p25, and this group is also present on RNO6.
This suggests the existence of a novel BMP-regulated "conditional" targeting activity of Az that is distinct from the constitutive targeting activity of Az towards ODC.
However, unlike the known ability of Az to bind ODC constitutively, the interaction between SNIP1 and Az is dependent upon the activation of BMP type I receptor and occurs in the presence of Smad1 and Smad4.
The 26S proteasome is responsible for the bulk turnover of cytoplasmic and nuclear proteins in eukaryotic cells and also plays a key role in the regulation of cell cycle, signal transduction, transcription as well as antigen presentation [ 17 18 19 20 21 ] . Most of the known proteasomal substrates are marked and targeted to proteasome by ubiquitination [ 17 19 20 ] . Ubiquitination, however, is not an obligatory step for substrate targeting to proteasome [ 17 18 20 ] . The degradation of the ornithine decarboxylase (ODC), the rate-limiting enzyme for polyamine synthesis, involves a protein named antizyme (Az), which binds and targets ODC to 26S proteasome for degradation [ 18 ] . However, ODC has remained an "orphan" in Az-dependent proteasomal degradation.
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